Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants

Research output: Contribution to journalArticlepeer-review


Objective: To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study. Study design: Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network’s (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis. Result: One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development. Conclusion: Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.

Original languageEnglish
Pages (from-to)286-294
Number of pages9
JournalJournal of Perinatology
Issue number2
StatePublished - Feb 2021

Bibliographical note

Funding Information:
Funding The study was supported by the Children’s Miracle Network (CT). The National Institutes of Health (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR24979) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, U10 HD53109) provided grant support for the Neonatal Research Network’s Glutamine trial and Genomics secondary study. JCM received assistance for the GENEVA study from the National Human Genome Research Institute (U01 HG4423). MEH received funding from the National Eye Institute (2R01EY015130, 5R01EY017011) and a Department Grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Science. The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies.

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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