Genetic recombination in brome mosaic virus: Effect of sequence and replication of RNA on accumulation of recombinants

P. D. Nagy, J. J. Bujarski

Research output: Contribution to journalComment/debate

46 Scopus citations

Abstract

In order to facilitate the isolation of recombinants in brome mosaic virus, a series of duplication mutants with alterations in the RNA3 3' noncoding region has been engineered. The distribution of crossovers, which was observed to be dependent on the parental RNA3 sequence, supported the role of RNA structure in recombination. However, a negative correlation between replication of the parental RNA3 constructs and the accumulation of recombinant progeny confirmed the role of selection.

Original languageEnglish
Pages (from-to)6824-6828
Number of pages5
JournalJournal of Virology
Volume66
Issue number11
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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