TY - JOUR
T1 - Genetic regulation
T2 - The lac control region
AU - Dickson, Robert C.
AU - Abelson, John
AU - Barnes, Wayne M.
AU - Reznikoff, William S.
PY - 1975
Y1 - 1975
N2 - The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.
AB - The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.
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U2 - 10.1126/science.1088926
DO - 10.1126/science.1088926
M3 - Review article
C2 - 1088926
AN - SCOPUS:0016427510
SN - 0036-8075
VL - 187
SP - 27
EP - 35
JO - Science
JF - Science
IS - 4171
ER -