TY - JOUR
T1 - Genetic Vulnerability to Drug Abuse
T2 - The D2 Dopamine Receptor Taq I B1 Restriction Fragment Length Polymorphism Appears More Frequently in Polysubstance Abusers
AU - Smith, Stevens S.
AU - O'Hara, Bruce F.
AU - Persico, Antonio M.
AU - Gorelick, David A.
AU - Newlin, David B.
AU - Vlahov, David
AU - Solomon, Liza
AU - Pickens, Roy
AU - Uhl, George R.
PY - 1992/9
Y1 - 1992/9
N2 - Alcoholics are more likely than nonalcoholics to display the Taq I A1 restriction fragment length polymorphism of the D2 dopamine receptor gene, according to four of six studies that examined alcoholics and controls. The current study examines whether the association observed in alcoholism might extend to other addictive substances by examining D2 dopamine receptor Taq IA and B restriction fragment length polymorphisms in polysubstance users and controls free of significant substance use. We hypothesized a stronger association for the B1 restriction fragment length polymorphism since it lies closer to dopamine receptor protein coding and 5' regulatory regions. Heavy polysubstance users and subjects with DSM-III-R psychoactive substance use diagnoses displayed significantly higher Taq I B1 frequencies than control subjects; Taq I A1 results for these comparisons were less robust. These results are consistent with a role for a D2 dopamine receptor gene variant marked by these restriction fragment length polymorphisms in enhanced substance abuse vulnerability.
AB - Alcoholics are more likely than nonalcoholics to display the Taq I A1 restriction fragment length polymorphism of the D2 dopamine receptor gene, according to four of six studies that examined alcoholics and controls. The current study examines whether the association observed in alcoholism might extend to other addictive substances by examining D2 dopamine receptor Taq IA and B restriction fragment length polymorphisms in polysubstance users and controls free of significant substance use. We hypothesized a stronger association for the B1 restriction fragment length polymorphism since it lies closer to dopamine receptor protein coding and 5' regulatory regions. Heavy polysubstance users and subjects with DSM-III-R psychoactive substance use diagnoses displayed significantly higher Taq I B1 frequencies than control subjects; Taq I A1 results for these comparisons were less robust. These results are consistent with a role for a D2 dopamine receptor gene variant marked by these restriction fragment length polymorphisms in enhanced substance abuse vulnerability.
UR - http://www.scopus.com/inward/record.url?scp=0026670871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026670871&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1992.01820090051009
DO - 10.1001/archpsyc.1992.01820090051009
M3 - Article
C2 - 1355337
AN - SCOPUS:0026670871
SN - 0003-990X
VL - 49
SP - 723
EP - 727
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 9
ER -