Genetics, genomics and evolution of ergot alkaloid diversity

Carolyn A. Young, Christopher L. Schardl, Daniel G. Panaccione, Simona Florea, Johanna E. Takach, Nikki D. Charlton, Neil Moore, Jennifer S. Webb, Jolanta Jaromczyk

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

The ergot alkaloid biosynthesis system has become an excellent model to study evolutionary diversification of specialized (secondary) metabolites. This is a very diverse class of alkaloids with various neurotropic activities, produced by fungi in several orders of the phylum Ascomycota, including plant pathogens and protective plant symbionts in the family Clavicipitaceae. Results of comparative genomics and phylogenomic analyses reveal multiple examples of three evolutionary processes that have generated ergot-alkaloid diversity: gene gains, gene losses, and gene sequence changes that have led to altered substrates or product specificities of the enzymes that they encode (neofunctionalization). The chromosome ends appear to be particularly effective engines for gene gains, losses and rearrangements, but not necessarily for neofunctionalization. Changes in gene expression could lead to accumulation of various pathway intermediates and affect levels of different ergot alkaloids. Genetic alterations associated with interspecific hybrids of Epichloë species suggest that such variation is also selectively favored. The huge structural diversity of ergot alkaloids probably represents adaptations to a wide variety of ecological situations by affecting the biological spectra and mechanisms of defense against herbivores, as evidenced by the diverse pharmacological effects of ergot alkaloids used in medicine.

Original languageEnglish
Pages (from-to)1273-1302
Number of pages30
JournalToxins
Volume7
Issue number4
DOIs
StatePublished - Apr 14 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

  • Chanoclavine
  • Claviceps
  • Clavicipitaceae
  • Epichloë
  • Ergopeptine
  • Gene clusters
  • Natural products
  • Periglandula
  • Secondary metabolism
  • Subterminal

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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