Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo Ladu, David W. Fardo, G. William Rebeck, Steven Estus

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.

Original languageEnglish
Article number48
JournalMolecular Neurodegeneration
Issue number1
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Malik et al.


  • ABCA7
  • APOE
  • Alzheimer's disease
  • CD33
  • CR1
  • GWAS
  • Microglia
  • Neuroinflammation
  • SHIP1
  • TREM2

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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