Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik; Ishita Parikh; Jared B. Vasquez; Conor Smith; Leon Tai; Guojun Bu; Mary Jo Ladu; David W. Fardo; G. William Rebeck; Steven Estus

doi:10.1186/s13024-015-0048-1

Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo Ladu, David W. Fardo, G. William Rebeck, Steven Estus

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.

Original language	English
Article number	48
Journal	Molecular Neurodegeneration
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13024-015-0048-1
State	Published - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Malik et al.

Funding

Funders	Funder number
National Institutes of Health (NIH)
National Institute on Aging	K25AG043546
National Institute on Aging

Keywords

ABCA7
APOE
Alzheimer's disease
CD33
CR1
GWAS
Microglia
Neuroinflammation
SHIP1
TREM2

ASJC Scopus subject areas

Molecular Biology
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1186/s13024-015-0048-1

Cite this

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abstract = "In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.",

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AU - Parikh, Ishita

AU - Vasquez, Jared B.

AU - Smith, Conor

AU - Tai, Leon

AU - Bu, Guojun

AU - Ladu, Mary Jo

AU - Fardo, David W.

AU - Rebeck, G. William

AU - Estus, Steven

PY - 2015/12/1

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KW - CR1

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KW - TREM2

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Genetics ignite focus on microglial inflammation in Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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