Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

Aldi T. Kraja; Steven C. Hunt; D. C. Rao; Victor G. Dávila-Román; Donna K. Arnett; Michael A. Province

doi:10.1007/s11906-010-0174-7

Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

Aldi T. Kraja, Steven C. Hunt, D. C. Rao, Victor G. Dávila-Román, Donna K. Arnett, Michael A. Province

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.

Original language	English
Pages (from-to)	46-54
Number of pages	9
Journal	Current Hypertension Reports
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s11906-010-0174-7
State	Published - Feb 2011

Bibliographical note

Funding Information:
Acknowledgment This work was supported in part by the National Institutes of Health (NIH) HyperGEN Study grant U01 HL54471 and in part by the NIH Genetic Determinants of the LVH Phenotype grant RO1 HL07178205A.

Funding

Acknowledgment This work was supported in part by the National Institutes of Health (NIH) HyperGEN Study grant U01 HL54471 and in part by the NIH Genetic Determinants of the LVH Phenotype grant RO1 HL07178205A.

Funders	Funder number
National Institutes of Health (NIH)	RO1 HL07178205A
National Heart, Lung, and Blood Institute (NHLBI)	U01HL054471

Keywords

Blood pressure
Cardiovascular disease
GWAS
Genome-wide association studies
Hypertension
Pathways
SNPs
Single nucleotide polymorphisms

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11906-010-0174-7

Cite this

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abstract = "Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.",

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note = "Funding Information: Acknowledgment This work was supported in part by the National Institutes of Health (NIH) HyperGEN Study grant U01 HL54471 and in part by the NIH Genetic Determinants of the LVH Phenotype grant RO1 HL07178205A.",

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AU - Arnett, Donna K.

AU - Province, Michael A.

N1 - Funding Information: Acknowledgment This work was supported in part by the National Institutes of Health (NIH) HyperGEN Study grant U01 HL54471 and in part by the NIH Genetic Determinants of the LVH Phenotype grant RO1 HL07178205A.

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Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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