Genome sequence, comparative analysis, and population genetics of the domestic horse

C. M. Wade; E. Giulotto; S. Sigurdsson; M. Zoli; S. Gnerre; F. Imsland; T. L. Lear; D. L. Adelson; E. Bailey; R. R. Bellone; H. Blöcker; O. Distl; R. C. Edgar; M. Garber; T. Leeb; E. Mauceli; J. N. MacLeod; M. C.T. Penedo; J. M. Raison; T. Sharpe; J. Vogel; L. Andersson; D. F. Antczak; T. Biagi; M. M. Binns; B. P. Chowdhary; S. J. Coleman; G. Della Valle; S. Fryc; G. Guérin; T. Hasegawa; E. W. Hill; J. Jurka; A. Kiialainen; G. Lindgren; J. Liu; E. Magnani; J. R. Mickelson; J. Murray; S. G. Nergadze; R. Onofrio; S. Pedroni; M. F. Piras; T. Raudsepp; M. Rocchi; K. H. Røed; O. A. Ryder; S. Searle; L. Skow; J. E. Swinburne; A. C. Syvänen; T. Tozaki; S. J. Valberg; M. Vaudin; J. R. White; M. C. Zody; E. S. Lander; K. Lindblad-Toh

doi:10.1126/science.1178158

Genome sequence, comparative analysis, and population genetics of the domestic horse

C. M. Wade
, E. Giulotto
, S. Sigurdsson
, M. Zoli
, S. Gnerre
, F. Imsland
, T. L. Lear
, D. L. Adelson
, E. Bailey
, R. R. Bellone
, H. Blöcker
, O. Distl
, R. C. Edgar
, M. Garber
, T. Leeb
, E. Mauceli
, J. N. MacLeod
, M. C.T. Penedo
, J. M. Raison
, T. Sharpe

J. Vogel, L. Andersson, D. F. Antczak, T. Biagi, M. M. Binns, B. P. Chowdhary, S. J. Coleman, G. Della Valle, S. Fryc, G. Guérin, T. Hasegawa, E. W. Hill, J. Jurka, A. Kiialainen, G. Lindgren, J. Liu, E. Magnani, J. R. Mickelson, J. Murray, S. G. Nergadze, R. Onofrio, S. Pedroni, M. F. Piras, T. Raudsepp, M. Rocchi, K. H. Røed, O. A. Ryder, S. Searle, L. Skow, J. E. Swinburne, A. C. Syvänen, T. Tozaki, S. J. Valberg, M. Vaudin, J. R. White, M. C. Zody, E. S. Lander, K. Lindblad-Toh

Research output: Contribution to journal › Article › peer-review

685 Scopus citations

Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Original language	English
Pages (from-to)	865-867
Number of pages	3
Journal	Science
Volume	326
Issue number	5954
DOIs	https://doi.org/10.1126/science.1178158
State	Published - Nov 6 2009

Funding

Funders	Funder number
National Human Genome Research Institute	U54HG003067
National Human Genome Research Institute
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung	116101
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1178158

Cite this

Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R. R., Blöcker, H., Distl, O., Edgar, R. C., Garber, M., Leeb, T., Mauceli, E., MacLeod, J. N., Penedo, M. C. T., Raison, J. M., ... Lindblad-Toh, K. (2009). Genome sequence, comparative analysis, and population genetics of the domestic horse. Science, 326(5954), 865-867. https://doi.org/10.1126/science.1178158

@article{bbb819d5296e488390b3fe0845098537,

title = "Genome sequence, comparative analysis, and population genetics of the domestic horse",

abstract = "We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53\% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.",

author = "Wade, \{C. M.\} and E. Giulotto and S. Sigurdsson and M. Zoli and S. Gnerre and F. Imsland and Lear, \{T. L.\} and Adelson, \{D. L.\} and E. Bailey and Bellone, \{R. R.\} and H. Bl{\"o}cker and O. Distl and Edgar, \{R. C.\} and M. Garber and T. Leeb and E. Mauceli and MacLeod, \{J. N.\} and Penedo, \{M. C.T.\} and Raison, \{J. M.\} and T. Sharpe and J. Vogel and L. Andersson and Antczak, \{D. F.\} and T. Biagi and Binns, \{M. M.\} and Chowdhary, \{B. P.\} and Coleman, \{S. J.\} and \{Della Valle\}, G. and S. Fryc and G. Gu{\'e}rin and T. Hasegawa and Hill, \{E. W.\} and J. Jurka and A. Kiialainen and G. Lindgren and J. Liu and E. Magnani and Mickelson, \{J. R.\} and J. Murray and Nergadze, \{S. G.\} and R. Onofrio and S. Pedroni and Piras, \{M. F.\} and T. Raudsepp and M. Rocchi and R{\o}ed, \{K. H.\} and Ryder, \{O. A.\} and S. Searle and L. Skow and Swinburne, \{J. E.\} and Syv{\"a}nen, \{A. C.\} and T. Tozaki and Valberg, \{S. J.\} and M. Vaudin and White, \{J. R.\} and Zody, \{M. C.\} and Lander, \{E. S.\} and K. Lindblad-Toh",

year = "2009",

month = nov,

day = "6",

doi = "10.1126/science.1178158",

language = "English",

volume = "326",

pages = "865--867",

number = "5954",

}

Wade, CM, Giulotto, E, Sigurdsson, S, Zoli, M, Gnerre, S, Imsland, F, Lear, TL, Adelson, DL, Bailey, E, Bellone, RR, Blöcker, H, Distl, O, Edgar, RC, Garber, M, Leeb, T, Mauceli, E, MacLeod, JN, Penedo, MCT, Raison, JM, Sharpe, T, Vogel, J, Andersson, L, Antczak, DF, Biagi, T, Binns, MM, Chowdhary, BP, Coleman, SJ, Della Valle, G, Fryc, S, Guérin, G, Hasegawa, T, Hill, EW, Jurka, J, Kiialainen, A, Lindgren, G, Liu, J, Magnani, E, Mickelson, JR, Murray, J, Nergadze, SG, Onofrio, R, Pedroni, S, Piras, MF, Raudsepp, T, Rocchi, M, Røed, KH, Ryder, OA, Searle, S, Skow, L, Swinburne, JE, Syvänen, AC, Tozaki, T, Valberg, SJ, Vaudin, M, White, JR, Zody, MC, Lander, ES & Lindblad-Toh, K 2009, 'Genome sequence, comparative analysis, and population genetics of the domestic horse', Science, vol. 326, no. 5954, pp. 865-867. https://doi.org/10.1126/science.1178158

TY - JOUR

T1 - Genome sequence, comparative analysis, and population genetics of the domestic horse

AU - Wade, C. M.

AU - Giulotto, E.

AU - Sigurdsson, S.

AU - Zoli, M.

AU - Gnerre, S.

AU - Imsland, F.

AU - Lear, T. L.

AU - Adelson, D. L.

AU - Bailey, E.

AU - Bellone, R. R.

AU - Blöcker, H.

AU - Distl, O.

AU - Edgar, R. C.

AU - Garber, M.

AU - Leeb, T.

AU - Mauceli, E.

AU - MacLeod, J. N.

AU - Penedo, M. C.T.

AU - Raison, J. M.

AU - Sharpe, T.

AU - Vogel, J.

AU - Andersson, L.

AU - Antczak, D. F.

AU - Biagi, T.

AU - Binns, M. M.

AU - Chowdhary, B. P.

AU - Coleman, S. J.

AU - Della Valle, G.

AU - Fryc, S.

AU - Guérin, G.

AU - Hasegawa, T.

AU - Hill, E. W.

AU - Jurka, J.

AU - Kiialainen, A.

AU - Lindgren, G.

AU - Liu, J.

AU - Magnani, E.

AU - Mickelson, J. R.

AU - Murray, J.

AU - Nergadze, S. G.

AU - Onofrio, R.

AU - Pedroni, S.

AU - Piras, M. F.

AU - Raudsepp, T.

AU - Rocchi, M.

AU - Røed, K. H.

AU - Ryder, O. A.

AU - Searle, S.

AU - Skow, L.

AU - Swinburne, J. E.

AU - Syvänen, A. C.

AU - Tozaki, T.

AU - Valberg, S. J.

AU - Vaudin, M.

AU - White, J. R.

AU - Zody, M. C.

AU - Lander, E. S.

AU - Lindblad-Toh, K.

PY - 2009/11/6

Y1 - 2009/11/6

N2 - We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

AB - We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

UR - https://www.scopus.com/pages/publications/70449379045

UR - https://www.scopus.com/pages/publications/70449379045#tab=citedBy

U2 - 10.1126/science.1178158

DO - 10.1126/science.1178158

M3 - Article

C2 - 19892987

AN - SCOPUS:70449379045

SN - 0036-8075

VL - 326

SP - 865

EP - 867

JO - Science

JF - Science

IS - 5954

ER -

Genome sequence, comparative analysis, and population genetics of the domestic horse

Abstract

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ASJC Scopus subject areas

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