Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

Original languageEnglish
Article number436
JournalBMC Genomics
StatePublished - Jun 29 2016

Bibliographical note

Funding Information:
Publication of this article was funded by Brigham Young University’s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at articles/supplements/volume-17-supplement-3.

Publisher Copyright:
© 2016 The Author(s).


  • Association
  • CSF
  • Genetics
  • Plasma
  • Prolactin

ASJC Scopus subject areas

  • Biotechnology
  • Genetics


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