Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

doi:10.1186/s12864-016-2785-0

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

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Abstract

Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10^-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

Original language	English
Article number	436
Journal	BMC Genomics
Volume	17
DOIs	https://doi.org/10.1186/s12864-016-2785-0
State	Published - Jun 29 2016

Bibliographical note

Funding Information:
Publication of this article was funded by Brigham Young University’s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at https://bmcgenomics.biomedcentral.com/ articles/supplements/volume-17-supplement-3.

Publisher Copyright:
© 2016 The Author(s).

Keywords

Association
CSF
Genetics
Plasma
Prolactin

ASJC Scopus subject areas

Biotechnology
Genetics

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10.1186/s12864-016-2785-0

Cite this

@article{4ced83b963974530ba7392ced6ceebea,

title = "Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid",

abstract = "Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.",

keywords = "Association, CSF, Genetics, Plasma, Prolactin",

author = "Staley, {Lyndsay A.} and Ebbert, {Mark T.W.} and Sheradyn Parker and Matthew Bailey and Michael Weiner and Paul Aisen and Ronald Petersen and Jack, {Clifford R.} and William Jagust and Trojanowki, {John Q.} and Toga, {Arthur W.} and Laurel Beckett and Green, {Robert C.} and Saykin, {Andrew J.} and John Morris and Shaw, {Leslie M.} and Ridge, {Perry G.} and Goate, {Alison M.} and Kauwe, {John S.K.}",

note = "Funding Information: Publication of this article was funded by Brigham Young University{\textquoteright}s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at https://bmcgenomics.biomedcentral.com/ articles/supplements/volume-17-supplement-3. Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = jun,

day = "29",

doi = "10.1186/s12864-016-2785-0",

language = "English",

volume = "17",

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T1 - Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

AU - Staley, Lyndsay A.

AU - Ebbert, Mark T.W.

AU - Parker, Sheradyn

AU - Bailey, Matthew

AU - Weiner, Michael

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Jagust, William

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Beckett, Laurel

AU - Green, Robert C.

AU - Saykin, Andrew J.

AU - Morris, John

AU - Shaw, Leslie M.

AU - Ridge, Perry G.

AU - Goate, Alison M.

AU - Kauwe, John S.K.

N1 - Funding Information: Publication of this article was funded by Brigham Young University’s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at https://bmcgenomics.biomedcentral.com/ articles/supplements/volume-17-supplement-3. Publisher Copyright: © 2016 The Author(s).

PY - 2016/6/29

Y1 - 2016/6/29

N2 - Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

AB - Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

KW - Association

KW - CSF

KW - Genetics

KW - Plasma

KW - Prolactin

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JO - BMC Genomics

JF - BMC Genomics

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ER -

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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