Abstract
Varicella Zoster Virus (VZV) is the causative agent of varicella and herpes zoster. Although it is well established that VZV is transmitted via the respiratory route, the host-pathogen interactions during acute VZV infection in the lungs remain poorly understood due to limited access to clinical samples. To address these gaps in our knowledge, we leveraged a nonhuman primate model of VZV infection where rhesus macaques are intrabronchially challenged with the closely related Simian Varicella Virus (SVV). Acute infection is characterized by immune infiltration of the lung airways, a significant up-regulation of genes involved in antiviral-immunity, and a down-regulation of genes involved in lung development. This is followed by a decrease in viral loads and increased expression of genes associated with cell cycle and tissue repair. These data provide the first characterization of the host response required to control varicella virus replication in the lung and provide insight into mechanisms by which VZV infection can cause lung injury in an immune competent host.
| Original language | English |
|---|---|
| Article number | 34164 |
| Journal | Scientific Reports |
| Volume | 6 |
| DOIs | |
| State | Published - Sep 28 2016 |
Bibliographical note
Publisher Copyright:© The Author(s) 2016.
Funding
We thank the veterinarians and the husbandry staff at the Oregon National Primate Research Center for their expert care of the animals. We also would like to thank Melanie Oaks at the University of California, Irvine genomics core and the staff at the University of California, Riverside genomics core for sequencing our RNA libraries.
| Funders |
|---|
| Melanie Oaks at the University of California, Irvine |
ASJC Scopus subject areas
- General
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