Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

Anye Wamucho; Jason M. Unrine; Troy J. Kieran; Travis C. Glenn; Carolin L. Schultz; Mark Farman; Claus Svendsen; David J. Spurgeon; Olga V. Tsyusko

doi:10.1016/j.envpol.2019.113078

Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

Anye Wamucho, Jason M. Unrine, Troy J. Kieran, Travis C. Glenn, Carolin L. Schultz, Mark Farman, Claus Svendsen, David J. Spurgeon, Olga V. Tsyusko

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Multigenerational exposure to pristine and sulfidized Ag nanoparticles is characterized with overall increases in germline mutations.

Original language	English
Article number	113078
Journal	Environmental Pollution
Volume	254
DOIs	https://doi.org/10.1016/j.envpol.2019.113078
State	Published - Nov 2019

Bibliographical note

Funding Information:
The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation ( NSF ) under EF-0830093 , DBI-1266252 , and CBET-1530594 . C.L.S. was supported by the EU 7th Framework Programme , Marie Curie Actions, ITN NanoTOES ( PITN-GA-2010-264506 ). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano ( CP-FP7 604387 ). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs ( P40 D010440 ). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred.

Funding Information:
The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation (NSF) under EF-0830093, DBI-1266252, and CBET-1530594. C.L.S. was supported by the EU 7th Framework Programme, Marie Curie Actions, ITN NanoTOES (PITN-GA-2010-264506). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano (CP-FP7 604387). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs (P40 D010440). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Genotoxicity
Germline
Nanomaterials
Nematode
Variants

ASJC Scopus subject areas

Toxicology
Pollution
Health, Toxicology and Mutagenesis

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10.1016/j.envpol.2019.113078

Cite this

@article{73cc73e6035947fd8c5c8be538fd3d9b,

title = "Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles",

abstract = "Multigenerational exposure to pristine and sulfidized Ag nanoparticles is characterized with overall increases in germline mutations.",

keywords = "Genotoxicity, Germline, Nanomaterials, Nematode, Variants",

author = "Anye Wamucho and Unrine, {Jason M.} and Kieran, {Troy J.} and Glenn, {Travis C.} and Schultz, {Carolin L.} and Mark Farman and Claus Svendsen and Spurgeon, {David J.} and Tsyusko, {Olga V.}",

note = "Funding Information: The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation ( NSF ) under EF-0830093 , DBI-1266252 , and CBET-1530594 . C.L.S. was supported by the EU 7th Framework Programme , Marie Curie Actions, ITN NanoTOES ( PITN-GA-2010-264506 ). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano ( CP-FP7 604387 ). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs ( P40 D010440 ). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred. Funding Information: The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation (NSF) under EF-0830093, DBI-1266252, and CBET-1530594. C.L.S. was supported by the EU 7th Framework Programme, Marie Curie Actions, ITN NanoTOES (PITN-GA-2010-264506). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano (CP-FP7 604387). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs (P40 D010440). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = nov,

doi = "10.1016/j.envpol.2019.113078",

language = "English",

volume = "254",

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T1 - Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

AU - Wamucho, Anye

AU - Unrine, Jason M.

AU - Kieran, Troy J.

AU - Glenn, Travis C.

AU - Schultz, Carolin L.

AU - Farman, Mark

AU - Svendsen, Claus

AU - Spurgeon, David J.

AU - Tsyusko, Olga V.

N1 - Funding Information: The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation ( NSF ) under EF-0830093 , DBI-1266252 , and CBET-1530594 . C.L.S. was supported by the EU 7th Framework Programme , Marie Curie Actions, ITN NanoTOES ( PITN-GA-2010-264506 ). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano ( CP-FP7 604387 ). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs ( P40 D010440 ). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred. Funding Information: The authors gratefully acknowledge J. Jaromczyk, S. Lichtenberg, and T.H. Bair for assisting with data analysis. S. Shrestha assisted with laboratory work and Z. E. Baddar helped with XRD analysis. This work was supported by the U.S. National Science Foundation (NSF) under EF-0830093, DBI-1266252, and CBET-1530594. C.L.S. was supported by the EU 7th Framework Programme, Marie Curie Actions, ITN NanoTOES (PITN-GA-2010-264506). C.S. receive support from National Capability funding through the UK NERC Centre for Ecology and Hydrology Pollution and Environmental Risk Theme and the EU FP7 project GUIDEnano (CP-FP7 604387). Caenorhabditis elegans strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs (P40 D010440). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA or NSF. This work has not been subjected to EPA or NSF review, and no official endorsement should be inferred. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/11

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N2 - Multigenerational exposure to pristine and sulfidized Ag nanoparticles is characterized with overall increases in germline mutations.

AB - Multigenerational exposure to pristine and sulfidized Ag nanoparticles is characterized with overall increases in germline mutations.

KW - Genotoxicity

KW - Germline

KW - Nanomaterials

KW - Nematode

KW - Variants

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Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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