Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.
|Number of pages||4|
|State||Published - 2016|
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health (5R01GM107586). We would like to thank the University of Kentucky Environmental Research Training Laboratory (ERTL) for their assistance in some chemical analysis.
© 2016 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry (all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry