Geometry matters: Inverse cytotoxic relationship for: Cis / trans -Ru(II) polypyridyl complexes from cis / trans -[PtCl2(NH3)2]

Erin Wachter; Ana Zamora; David K. Heidary; José Ruiz; Edith C. Glazer

doi:10.1039/c6cc04813g

Geometry matters: Inverse cytotoxic relationship for: Cis / trans -Ru(II) polypyridyl complexes from cis / trans -[PtCl₂(NH₃)₂]

Erin Wachter, Ana Zamora, David K. Heidary, José Ruiz, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)₂Cl₂ and trans-Ru(qpy)Cl₂ were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl₂ was 7.1-9.5× more cytotoxic than cis-Ru(bpy)₂Cl₂. This discovery could open up a new area of metal-based chemotherapeutic research.

Original language	English
Pages (from-to)	10121-10124
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	66
DOIs	https://doi.org/10.1039/c6cc04813g
State	Published - 2016

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (5R01GM107586). We would like to thank the University of Kentucky Environmental Research Training Laboratory (ERTL) for their assistance in some chemical analysis.

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry (all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c6cc04813g

Cite this

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title = "Geometry matters: Inverse cytotoxic relationship for: Cis / trans -Ru(II) polypyridyl complexes from cis / trans -[PtCl2(NH3)2]",

abstract = "Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.",

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AU - Ruiz, José

AU - Glazer, Edith C.

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