Geometry matters: Inverse cytotoxic relationship for: Cis / trans -Ru(II) polypyridyl complexes from cis / trans -[PtCl2(NH3)2]

Erin Wachter, Ana Zamora, David K. Heidary, José Ruiz, Edith C. Glazer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.

Original languageEnglish
Pages (from-to)10121-10124
Number of pages4
JournalChemical Communications
Volume52
Issue number66
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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