TY - JOUR
T1 - Germline Mutations in African American Men With Prostate Cancer
T2 - Incidence, Implications and Diagnostic Disparities
AU - Bree, Kelly K.
AU - Hensley, Patrick J.
AU - Pettaway, Curtis A.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.
AB - Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.
UR - http://www.scopus.com/inward/record.url?scp=85115157591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85115157591&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2021.08.017
DO - 10.1016/j.urology.2021.08.017
M3 - Review article
C2 - 34453957
AN - SCOPUS:85115157591
SN - 0090-4295
VL - 163
SP - 148
EP - 155
JO - Urology
JF - Urology
ER -
