Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities

Kelly K. Bree, Patrick J. Hensley, Curtis A. Pettaway

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalUrology
Volume163
DOIs
StatePublished - May 2022

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

ASJC Scopus subject areas

  • Urology

Fingerprint

Dive into the research topics of 'Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities'. Together they form a unique fingerprint.

Cite this