Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities

Kelly K. Bree; Patrick J. Hensley; Curtis A. Pettaway

doi:10.1016/j.urology.2021.08.017

Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities

Kelly K. Bree
, Patrick J. Hensley
, Curtis A. Pettaway

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.

Original language	English
Pages (from-to)	148-155
Number of pages	8
Journal	Urology
Volume	163
DOIs	https://doi.org/10.1016/j.urology.2021.08.017
State	Published - May 2022

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Funding

Declaration of Interests: The authors report the following financial interests. KB: Stratify genomics – consultant. Funding: None.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Urology

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10.1016/j.urology.2021.08.017

Cite this

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title = "Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities",

abstract = "Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.",

author = "Bree, \{Kelly K.\} and Hensley, \{Patrick J.\} and Pettaway, \{Curtis A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = may,

doi = "10.1016/j.urology.2021.08.017",

language = "English",

volume = "163",

pages = "148--155",

}

TY - JOUR

T1 - Germline Mutations in African American Men With Prostate Cancer

T2 - Incidence, Implications and Diagnostic Disparities

AU - Bree, Kelly K.

AU - Hensley, Patrick J.

AU - Pettaway, Curtis A.

PY - 2022/5

Y1 - 2022/5

N2 - Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.

AB - Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit genetic alterations in highly penetrant germline genes, as well as low penetrant single nucleotide polymorphisms. The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians with PCa, further studies are needed to facilitate potential reclassification of VUS. Ongoing efforts to include AAM in genomics research is of paramount importance in order to ensure applicability of discoveries across diverse populations and potentially reduce PCa disparities as we embark on the era of precision medicine.

UR - https://www.scopus.com/pages/publications/85115157591

UR - https://www.scopus.com/pages/publications/85115157591#tab=citedBy

U2 - 10.1016/j.urology.2021.08.017

DO - 10.1016/j.urology.2021.08.017

M3 - Review article

C2 - 34453957

AN - SCOPUS:85115157591

SN - 0090-4295

VL - 163

SP - 148

EP - 155

JO - Urology

JF - Urology

ER -

Germline Mutations in African American Men With Prostate Cancer: Incidence, Implications and Diagnostic Disparities

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

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