Global phenotypic screening for antimalarials

W. Armand Guiguemde, Anang A. Shelat, Jose F. Garcia-Bustos, Thierry T. Diagana, Francisco Javier Gamo, R. Kiplin Guy

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations

Abstract

Malaria, a devastating infectious disease caused by Plasmodium spp., leads to roughly 655,000 deaths per year, mostly of African children. To compound the problem, drug resistance has emerged to all classical antimalarials and may be emerging for artemisinin-based combination therapies. To address the need for new antimalarials with novel mechanisms, several groups carried out phenotypic screening campaigns to identify compounds inhibiting growth of the blood stages of Plasmodium falciparum. In this review, we describe the characterization of these compounds, explore currently ongoing strategies to develop lead molecules, and endorse the concept of a "malaria box" of publicly accessible active compounds.

Original languageEnglish
Pages (from-to)116-129
Number of pages14
JournalChemistry and Biology
Volume19
Issue number1
DOIs
StatePublished - Jan 27 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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