Glomerular lesions in male rabbits treated with aluminium lactate: With special reference to microaneurysm formation

C. B. Hong, Andrea M. Fredenburg, Kenneth M. Dickey, Mark A. Lovell, Robert A. Yokel

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Novel glomerular lesions were seen in male rabbits after intravenous administration of aluminum lactate. Eight rabbits in the treated group were given 0.1 mmol/kg of aluminum lactate 5 days a week for 4 weeks. The control group of 8 rabbits was given 0.3 mmol/kg of sodium lactate by the same injection protocol. In the treated group, the mesangial cells in the glomerular tufts in 6 of 8 rabbits were distended with grayish blue granular material, which was identified by laser microprobe mass spectrometry and acid solochrome azurine stain as an aluminum compound. Other consistent findings in the glomeruli included microaneurysm in 6 of 8 rabbits and segmental sclerosis in 6 of 8 rabbits. Less frequently observed glomerular changes included crescent formation, necrosis with calcification, fibrosis of the Bowman's capsule, cystic dilation of the Bowman's space, and exudation of erythrocytes into the Bowman's space. The mechanism by which aluminum lacrate induces the glomerular changes is not certain. However, the pathogenesis may involve the deposition of aluminum in the mesangial cells, resulting in mesangiolysis which in turn causes microaneurysm. The sclerotic change is interpreted as a sequela of microaneurysm. The findings suggest that aluminum induces glomerular lesions in rabbits. This may serve as a good animal model to study mesangiolysis and microaneurysm formation.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalExperimental and Toxicologic Pathology
Issue number2
StatePublished - May 2000

Bibliographical note

Funding Information:
Acknowledgments: This work was supported in part by NIH ES 4640 and T32 E37266.


  • Aluminium
  • Aluminium lactate
  • Aluminum toxicity
  • Glomerular
  • Glomerular microaneurysm
  • Kidney
  • Microaneurysm
  • Toxicity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology


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