Intensive pretreatment with triamcinoline diacetate (8 mg/kg, i.m. once daily for 7 days) was found in the acute spinal (decerebrate) cat to potentiate the increase in monosynaptic spinal reflex transmission caused by coadministration of the serotonin precursor, d, l-5-hydroxytryptophan, and amitriptyline, a selective serotonin reuptake inhibitor. In addition, the ability of methysergide, a selective serotonin receptor antagonist, to reverse the monosynaptic excitatory actions of d, l-5-hydroxytryptophan plus amitriptyline was significantly reduced. This apparent glucocorticoid enhancement of the actions of a serotonergic spinal system that is facilitatory to motor neuron excitation may have relevance to the therapy of degenerative motor neuron disorders.
|Number of pages||6|
|State||Published - Jun 1980|
Bibliographical noteFunding Information:
Abbreviations: 5-HTP-D,r-5hydroxytryptophan. ’ The author gratefully acknowledges the dedicated technical assistance of Mrs. Brigitte Hirst’and a gift of triamcinolone diacetate (Aristocort) from Lederle Laboratories of Pearl River, New York. The support for this project was provided by a grant from the Amyotrophic Lateral Sclerosis Society of America.
ASJC Scopus subject areas
- Developmental Neuroscience