Glucocorticoid modification of spinal dopamine receptor activation by apomorphine

Edward D. Hall, Carl V. Tyler

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosing significantly decreased the APO-induced depression of the spinal DRR, but not the similar action of APO on the MSR. This complex effect of triamcinolone on spinal dopaminergic activation by APO may represent a differential action of glucocorticoid on two types of spinal DA receptors with one type, but not the other, undergoing partial desensitization.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalBrain Research
Volume267
Issue number2
DOIs
StatePublished - May 16 1983

Bibliographical note

Funding Information:
nical assistancoe f Mrs. BrigitteH irst, the gift of triamcinoloned iacetate( Aristocort) from the LederleC o. of Pearl River, NY and the financial supporto f NIMH Grant 34111.

Keywords

  • apomorphine
  • dopamine
  • glucocorticoids
  • receptors
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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