Glucocorticoid modification of spinal dopamine receptor activation by apomorphine

Edward D. Hall; Carl V. Tyler

doi:10.1016/0006-8993(83)90894-6

Glucocorticoid modification of spinal dopamine receptor activation by apomorphine

Edward D. Hall, Carl V. Tyler

Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosing significantly decreased the APO-induced depression of the spinal DRR, but not the similar action of APO on the MSR. This complex effect of triamcinolone on spinal dopaminergic activation by APO may represent a differential action of glucocorticoid on two types of spinal DA receptors with one type, but not the other, undergoing partial desensitization.

Original language	English
Pages (from-to)	380-383
Number of pages	4
Journal	Brain Research
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90894-6
State	Published - May 16 1983

Bibliographical note

Funding Information:
nical assistancoe f Mrs. BrigitteH irst, the gift of triamcinoloned iacetate( Aristocort) from the LederleC o. of Pearl River, NY and the financial supporto f NIMH Grant 34111.

Funding

nical assistancoe f Mrs. BrigitteH irst, the gift of triamcinoloned iacetate( Aristocort) from the LederleC o. of Pearl River, NY and the financial supporto f NIMH Grant 34111.

Funders	Funder number
National Institute of Mental Health	34111

Keywords

apomorphine
dopamine
glucocorticoids
receptors
spinal cord

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)90894-6

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AB - The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosing significantly decreased the APO-induced depression of the spinal DRR, but not the similar action of APO on the MSR. This complex effect of triamcinolone on spinal dopaminergic activation by APO may represent a differential action of glucocorticoid on two types of spinal DA receptors with one type, but not the other, undergoing partial desensitization.

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KW - glucocorticoids

KW - receptors

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Glucocorticoid modification of spinal dopamine receptor activation by apomorphine

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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