TY - JOUR
T1 - Glucuronidation and UGT isozymes in bladder
T2 - New targets for the treatment of uroepithelial carcinomas?
AU - Sundararaghavan, Vikram L.
AU - Sindhwani, Puneet
AU - Hinds, Terry D.
PY - 2017
Y1 - 2017
N2 - Bladder cancer has been linked to numerous toxins which can be concentrated in the bladder after being absorbed into the blood and filtered by the kidneys. Excessive carcinogenic load to the bladder urothelium may result in the development of cancer. However, enzymes within the bladder can metabolize carcinogens into substrates that are safer. Importantly, these proteins, namely the UGT's (uridine 5'-diphospho-glucuronosyltransferases), have been shown to possibly prevent bladder cancer. Also, studies have shown that the UGT1 expression is decreased in uroepithelial carcinomas, which may allow for the accumulation of carcinogens in the bladder. In this review, we discuss the UGT system and its' protective role against bladder cancer, UGT genetic mutations that modulate risk from chemicals and environmental toxins, as well as targeting of the UGT enzymes by nuclear receptors.
AB - Bladder cancer has been linked to numerous toxins which can be concentrated in the bladder after being absorbed into the blood and filtered by the kidneys. Excessive carcinogenic load to the bladder urothelium may result in the development of cancer. However, enzymes within the bladder can metabolize carcinogens into substrates that are safer. Importantly, these proteins, namely the UGT's (uridine 5'-diphospho-glucuronosyltransferases), have been shown to possibly prevent bladder cancer. Also, studies have shown that the UGT1 expression is decreased in uroepithelial carcinomas, which may allow for the accumulation of carcinogens in the bladder. In this review, we discuss the UGT system and its' protective role against bladder cancer, UGT genetic mutations that modulate risk from chemicals and environmental toxins, as well as targeting of the UGT enzymes by nuclear receptors.
KW - Bladder cancer
KW - Glucuronidation
KW - Nuclear receptors
KW - UDP-G glycosyltransferase
KW - UGT
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U2 - 10.18632/oncotarget.12277
DO - 10.18632/oncotarget.12277
M3 - Review article
C2 - 27690298
AN - SCOPUS:85009742331
SN - 1949-2553
VL - 8
SP - 3640
EP - 3648
JO - Oncotarget
JF - Oncotarget
IS - 2
ER -