Glucuronidation and UGT isozymes in bladder: New targets for the treatment of uroepithelial carcinomas?

Vikram L. Sundararaghavan, Puneet Sindhwani, Terry D. Hinds

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Bladder cancer has been linked to numerous toxins which can be concentrated in the bladder after being absorbed into the blood and filtered by the kidneys. Excessive carcinogenic load to the bladder urothelium may result in the development of cancer. However, enzymes within the bladder can metabolize carcinogens into substrates that are safer. Importantly, these proteins, namely the UGT's (uridine 5'-diphospho-glucuronosyltransferases), have been shown to possibly prevent bladder cancer. Also, studies have shown that the UGT1 expression is decreased in uroepithelial carcinomas, which may allow for the accumulation of carcinogens in the bladder. In this review, we discuss the UGT system and its' protective role against bladder cancer, UGT genetic mutations that modulate risk from chemicals and environmental toxins, as well as targeting of the UGT enzymes by nuclear receptors.

Original languageEnglish
Pages (from-to)3640-3648
Number of pages9
JournalOncotarget
Volume8
Issue number2
DOIs
StatePublished - 2017

Keywords

  • Bladder cancer
  • Glucuronidation
  • Nuclear receptors
  • UDP-G glycosyltransferase
  • UGT

ASJC Scopus subject areas

  • Oncology

Fingerprint

Dive into the research topics of 'Glucuronidation and UGT isozymes in bladder: New targets for the treatment of uroepithelial carcinomas?'. Together they form a unique fingerprint.

Cite this