Glutamate transport and renal function

Tomas C. Welbourne, James C. Matthews

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Brush border γ-glutamyltransferase-glutaminase activity and the high- affinity glutamate transporter EAAC1 function as a unit in generating and transporting extracellular glutamate into proximal tubules as a signal that modulates intracellular glutamine/glutamate metabolism, paracellular permeability, and urinary acidification. The reported presence of a second glutamate transporter, GLT1, on the antiluminal tubule surface points to specific functional roles for each subtype in physiological and pathophysiological processes.

Original languageEnglish
Pages (from-to)F501-F505
JournalAmerican Journal of Physiology - Renal Physiology
Issue number4 46-4
StatePublished - Oct 1999


  • D-glutamate
  • EAAC1
  • GLT1
  • Paracellular permeability
  • Phosphate-dependent glutaminase
  • Urinary acidification
  • γ-glutamyltransferase

ASJC Scopus subject areas

  • Physiology
  • Urology


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