Glutathione reductase functions as vanadate(V) reductase

Xianglin Shi, N. S. Dalal

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The oxidation of NADPH by vanadate(V) in the presence of glutathione reductase showed typical enzymatic kinetics. The oxidation was inhibited by N-ethylmaleimide, a glutathione reductase inhibitor. Superoxide dismutase had no significant effect on the oxidation, indicating noninvolvment of the superoxide radical. The vanadate(V) reduction was found to be a one-electron transfer process. These results suggest a new pathway for vanadate(V) metabolism and a new function of glutathione reductase.

Original languageEnglish
Pages (from-to)288-290
Number of pages3
JournalArchives of Biochemistry and Biophysics
Volume278
Issue number1
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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