Glycoprotein B of bovine herpesvirus-1 binds heparin

Katherine M. Byrne; David W. Horohov; Konstantin G. Kousoulas

doi:10.1006/viro.1995.1248

Glycoprotein B of bovine herpesvirus-1 binds heparin

Katherine M. Byrne, David W. Horohov, Konstantin G. Kousoulas

Veterinary Science

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.

Original language	English
Article number	71248
Pages (from-to)	230-235
Number of pages	6
Journal	Virology
Volume	209
Issue number	1
DOIs	https://doi.org/10.1006/viro.1995.1248
State	Published - May 10 1995

ASJC Scopus subject areas

Virology

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10.1006/viro.1995.1248

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abstract = "Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.",

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AB - Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.

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Glycoprotein B of bovine herpesvirus-1 binds heparin

Abstract

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