Abstract
Sweetness & light! The glycosyloxyamine glycoside of calicheamicin was exploited to form neo-D-ribosides in one efficient chemoselective step. Assessment of the neoglycosides revealed only slight reductions in cytotoxicity or ability to cleave DNA compared to the parent aglycons. This study exposes a previously unrecognized method for efficient calicheamicin bioconjugation amenable to a wide range of cancer- selective targeting modalities.
Original language | English |
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Pages (from-to) | 774-776 |
Number of pages | 3 |
Journal | ChemMedChem |
Volume | 6 |
Issue number | 5 |
DOIs | |
State | Published - May 2 2011 |
Keywords
- Carbohydrates
- Enediynes
- Glycosides
- Glycosylation
- Natural products
ASJC Scopus subject areas
- Drug Discovery
- General Pharmacology, Toxicology and Pharmaceutics
- Molecular Medicine
- Biochemistry
- Pharmacology
- Organic Chemistry