Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

Aram Chang, Shanteri Singh, George N. Phillips, Jon S. Thorson

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations

Abstract

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

Original languageEnglish
Pages (from-to)800-808
Number of pages9
JournalCurrent Opinion in Biotechnology
Volume22
Issue number6
DOIs
StatePublished - Dec 2011

Bibliographical note

Funding Information:
The unpublished work presented was supported by NIH (AI52218, CA84374 and GM074901) and the Laura and Edward Kremers Chair in Natural Products Chemistry (J.S.T.). We thank Prof. Gavin Williams (NCSU Dept. Chem.) for helpful discussion and review of this manuscript and also Craig Bingman and other members of the Center for Eukaryotic Structural Genomics.

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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