Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

Aram Chang; Shanteri Singh; George N. Phillips; Jon S. Thorson

doi:10.1016/j.copbio.2011.04.013

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

Aram Chang, Shanteri Singh, George N. Phillips, Jon S. Thorson

Research output: Contribution to journal › Review article › peer-review

136 Scopus citations

Abstract

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

Original language	English
Pages (from-to)	800-808
Number of pages	9
Journal	Current Opinion in Biotechnology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.copbio.2011.04.013
State	Published - Dec 2011

Bibliographical note

Funding Information:
The unpublished work presented was supported by NIH (AI52218, CA84374 and GM074901) and the Laura and Edward Kremers Chair in Natural Products Chemistry (J.S.T.). We thank Prof. Gavin Williams (NCSU Dept. Chem.) for helpful discussion and review of this manuscript and also Craig Bingman and other members of the Center for Eukaryotic Structural Genomics.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.copbio.2011.04.013

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abstract = "Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.",

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AU - Singh, Shanteri

AU - Phillips, George N.

AU - Thorson, Jon S.

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AB - Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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