TY - JOUR
T1 - Gold nanoshelled liquid perfluorocarbon magnetic nanocapsules
T2 - A nanotheranostic platform for bimodal ultrasound/magnetic resonance imaging guided photothermal tumor ablation
AU - Ke, Hengte
AU - Wang, Jinrui
AU - Tong, Sheng
AU - Jin, Yushen
AU - Wang, Shumin
AU - Qu, Enze
AU - Bao, Gang
AU - Dai, Zhifei
PY - 2014
Y1 - 2014
N2 - Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.
AB - Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.
KW - Bimodal imaging
KW - Gold nanoshell
KW - Liquid perfluorocarbon nanocapules
KW - Photothermal therapy
KW - Superparamagnetic iron oxide nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84896706842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896706842&partnerID=8YFLogxK
U2 - 10.7150/thno.7275
DO - 10.7150/thno.7275
M3 - Article
C2 - 24396512
AN - SCOPUS:84896706842
SN - 1838-7640
VL - 4
SP - 12
EP - 23
JO - Theranostics
JF - Theranostics
IS - 1
ER -