Gold nanoshelled liquid perfluorocarbon magnetic nanocapsules: A nanotheranostic platform for bimodal ultrasound/magnetic resonance imaging guided photothermal tumor ablation

Hengte Ke, Jinrui Wang, Sheng Tong, Yushen Jin, Shumin Wang, Enze Qu, Gang Bao, Zhifei Dai

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.

Original languageEnglish
Pages (from-to)12-23
Number of pages12
JournalTheranostics
Volume4
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Bimodal imaging
  • Gold nanoshell
  • Liquid perfluorocarbon nanocapules
  • Photothermal therapy
  • Superparamagnetic iron oxide nanoparticles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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