Abstract
This study reports the histological effects of topical misoprostol, a synthetic PGE1 analog, administered in varying dosages on the resting canine gastric mucosa. Misoprostol did not macroscopically or microscopically damage the mucosa but its presumed permeability effects on the gastric vasculature induced marked edema of the mucosa and submucosa. Consistent features included increased thickness of both layers, dilated interglandular regions of the lamina propria, marked subepithe-lial edema, reduced depth and width of gastric foveolae, vasodilation of the vascular channels, reduced height of surface epithelial cells, swelling of their basolateral intercellular spaces, and increased amounts of surface adherent mucus. It is speculated that the mucosal edema, in addition to an increased mucus layer, may be important in the mechanism of gastric cytoprotection by increasing the distance of penetration or absorption for a mucosal-damaging agent, diluting its concentration, and disseminating any focal accumulations of red blood cells.
| Original language | English |
|---|---|
| Pages (from-to) | 40-46 |
| Number of pages | 7 |
| Journal | Experimental and Toxicologic Pathology |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1992 |
Bibliographical note
Funding Information:This study was supported by Grant # 55-01496 to Dr. J. Koo from the Canadian Surgical Research Fund. The authors thank G. D. SEARLE and Co. for the supply of misoprosto!. They also express their appreciation to CYNTHIA LONG for her technical assistance in preparing the histological sections and for typing the manuscript.
Keywords
- cytoprotection, gastric mucosa
- gastric lesions
- gastric mucosa, cytoprotection
- misoprostol
- mucosal damage, gastric
- prostaglandin E
- stomach, mucosa
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Cell Biology