Group Sequential Design for Randomized Phase III Trials under the Weibull Model

Jianrong Wu; Xiaoping Xiong

doi:10.1080/10543406.2014.971165

Group Sequential Design for Randomized Phase III Trials under the Weibull Model

Jianrong Wu, Xiaoping Xiong

Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In this article, a parametric sequential test is proposed under the Weibull model. The proposed test is asymptotically normal with an independent increment structure. The sample size for a fixed sample test is derived for the purpose of group sequential trial design. In addition, a multi-stage group sequential procedure is given under the Weibull model by applying the Brownian motion property of the test statistic and sequential conditional probability ratio test methodology.

Original language	English
Pages (from-to)	1190-1205
Number of pages	16
Journal	Journal of Biopharmaceutical Statistics
Volume	25
Issue number	6
DOIs	https://doi.org/10.1080/10543406.2014.971165
State	Published - Nov 2 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 Taylor & Francis Group, LLC.

Keywords

Brownian motion
Group sequential trial
Randomized clinical trial
Sample size
Time-to-event
Weibull distribution

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

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10.1080/10543406.2014.971165

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abstract = "In this article, a parametric sequential test is proposed under the Weibull model. The proposed test is asymptotically normal with an independent increment structure. The sample size for a fixed sample test is derived for the purpose of group sequential trial design. In addition, a multi-stage group sequential procedure is given under the Weibull model by applying the Brownian motion property of the test statistic and sequential conditional probability ratio test methodology.",

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author = "Jianrong Wu and Xiaoping Xiong",

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AB - In this article, a parametric sequential test is proposed under the Weibull model. The proposed test is asymptotically normal with an independent increment structure. The sample size for a fixed sample test is derived for the purpose of group sequential trial design. In addition, a multi-stage group sequential procedure is given under the Weibull model by applying the Brownian motion property of the test statistic and sequential conditional probability ratio test methodology.

KW - Brownian motion

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KW - Randomized clinical trial

KW - Sample size

KW - Time-to-event

KW - Weibull distribution

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Group Sequential Design for Randomized Phase III Trials under the Weibull Model

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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