Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

Qing Bai She, Jagat J. Mukherjee, Jin Sheng Huang, Karan S. Crilly, Zoltan Kiss

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3'-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalFEBS Letters
Volume469
Issue number2-3
DOIs
StatePublished - Mar 10 2000

Bibliographical note

Funding Information:
This work was supported by SOTA TEC FUND 343–6027.

Keywords

  • DNA synthesis
  • Fibroblast
  • Insulin
  • Mitogen-activated protein kinase
  • Placental alkaline phosphatase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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