Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

Qing Bai She; Jagat J. Mukherjee; Jin Sheng Huang; Karan S. Crilly; Zoltan Kiss

doi:10.1016/S0014-5793(00)01273-4

Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

Qing Bai She, Jagat J. Mukherjee, Jin Sheng Huang, Karan S. Crilly, Zoltan Kiss

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3'-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras. Copyright (C) 2000 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	163-167
Number of pages	5
Journal	FEBS Letters
Volume	469
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(00)01273-4
State	Published - Mar 10 2000

Bibliographical note

Funding Information:
This work was supported by SOTA TEC FUND 343–6027.

Keywords

DNA synthesis
Fibroblast
Insulin
Mitogen-activated protein kinase
Placental alkaline phosphatase

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0014-5793(00)01273-4

Cite this

@article{8c08e9db71834219a4c774f6eba1b7fb,

title = "Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts",

abstract = "Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3'-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras. Copyright (C) 2000 Federation of European Biochemical Societies.",

keywords = "DNA synthesis, Fibroblast, Insulin, Mitogen-activated protein kinase, Placental alkaline phosphatase",

author = "She, {Qing Bai} and Mukherjee, {Jagat J.} and Huang, {Jin Sheng} and Crilly, {Karan S.} and Zoltan Kiss",

note = "Funding Information: This work was supported by SOTA TEC FUND 343–6027.",

year = "2000",

month = mar,

day = "10",

doi = "10.1016/S0014-5793(00)01273-4",

language = "English",

volume = "469",

pages = "163--167",

number = "2-3",

}

TY - JOUR

T1 - Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

AU - She, Qing Bai

AU - Mukherjee, Jagat J.

AU - Huang, Jin Sheng

AU - Crilly, Karan S.

AU - Kiss, Zoltan

N1 - Funding Information: This work was supported by SOTA TEC FUND 343–6027.

PY - 2000/3/10

Y1 - 2000/3/10

N2 - Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3'-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3'-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - DNA synthesis

KW - Fibroblast

KW - Insulin

KW - Mitogen-activated protein kinase

KW - Placental alkaline phosphatase

UR - http://www.scopus.com/inward/record.url?scp=0034629427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034629427&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(00)01273-4

DO - 10.1016/S0014-5793(00)01273-4

M3 - Article

C2 - 10713264

AN - SCOPUS:0034629427

SN - 0014-5793

VL - 469

SP - 163

EP - 167

JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -

Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this