Guía de consenso de expertos para la monitorización terapéutica de drogas en neuropsicofarmacología

Translated title of the contribution: Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology

Carlos López-Jaramillo, Ana M. Díaz-Zuluaga, Jose de Leon, Georgios Schoretsanitis, Michael Paulzen, Stefan Unterecker, Markus Schwarz, Andreas Conca, Gerald Zernig, Gerhard Gründer, Ekkerhard Haen, Pierre Baumann, Niels Bergemann, Hans Willi Clement, Katharina Domschke, Gabriel Eckermann, Karin Egberts, Manfred Gerlach, Christine Greiner, Ursula Havemann-ReineckeGudrun Hefner, Renate Helmer, Ger Janssen, Eveline Jaquenoud-Sirot, Thomas Messer, Rainald Mössner, Matthias J. Müller, Bruno Pfuhlmann, Gerd Laux, Peter Riederer, Alois Saria, Bernd Schoppek, Margarete Silva Gracia, Benedikt Stegmann, Werner Steimer, Julia C. Stingl, Manfred Uhr, Sven Ulrich, Roland Waschgler, Gabriela Zurek, Christoph Hiemke

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Objectives: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation, and treatment guidance. TDM introduces a precision medicine tool in times of increasing awareness of the need for personalised treatment. In neurology and psychiatry, TDM can guide pharmacotherapy for patient subgroups such as children, adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance use disorders, individuals with pharmacokinetic peculiarities, and forensic patients. Clear indications for TDM include lack of clinical response in the therapeutic dose range, assessment of drug adherence, tolerability issues, and drug-drug interactions. Methods: Based upon existing literature, recommended therapeutic reference ranges, laboratory alert levels, and levels of recommendation to use TDM for dosage optimisation without specific indications, conversion factors, factors for calculation of dose-related drug concentrations, and metabolite-to-parent ratios were calculated. Results: This summary of the updated consensus guidelines by the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) offers the practical and theoretical knowledge for the integration of TDM as part of pharmacotherapy with neuro- psychiatric agents into clinical routine. Conclusions: The present guidelines for TDM application for neuropsychiatric agents aim to assist clinicians in enhancing safety and efficacy of treatment.

Translated title of the contributionConsensus guidelines for therapeutic drug monitoring in neuropsychopharmacology
Original languageSpanish
Pages (from-to)83-95
Number of pages13
JournalPsiquiatria Biologica
Volume27
Issue number3
DOIs
StatePublished - Sep 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier España, S.L.U. and Sociedad Española de Psiquiatría y Sociedad Española de Psiquiatría Biológica

Keywords

  • Drug interactions
  • Drug monitoring
  • Pharmacokinetics
  • Practice guideline
  • Psychopharmacology

ASJC Scopus subject areas

  • Psychiatry and Mental health

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