Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)

Maryam Zare Jeddi; Karen S. Galea; Jillian Ashley-Martin; Julianne Nassif; Tyler Pollock; Devika Poddalgoda; Konstantinos M. Kasiotis; Kyriaki Machera; Holger M. Koch; Marta Esteban López; Ming Kei Chung; Jihyon Kil; Kate Jones; Adrian Covaci; Yu Ait Bamai; Mariana F. Fernandez; Robert Pasanen Kase; Henriqueta Louro; Maria J. Silva; Tiina Santonen; Andromachi Katsonouri; Argelia Castaño; Lesliam Quirós-Alcalá; Elizabeth Ziying Lin; Krystal Pollitt; Ana Virgolino; Paul T.J. Scheepers; Lisa Jo Melnyk; Vicente Mustieles; Ana Isabel Cañas Portilla; Susana Viegas; Natalie von Goetz; Ovnair Sepai; Emily Bird; Thomas Göen; Silvia Fustinoni; Manosij Ghosh; Hubert Dirven; Jung Hwan Kwon; Courtney Carignan; Yuki Mizuno; Yuki Ito; Yankai Xia; Shoji F. Nakayama; Konstantinos C. Makris; Patrick J. Parsons; Melissa Gonzales; Michael Bader; Maria Dusinska; Aziza Menouni; Radu Corneliu Duca; Kaoutar Chbihi; Samir El Jaafari; Lode Godderis; An van Nieuwenhuyse; Asif Qureshi; Imran Ali; Carla Costa Trindade; Joao Paulo Teixeira; Alena Bartonova; Giovanna Tranfo; Karine Audouze; Steven Verpaele; Judy LaKind; Hans Mol; Jos Bessems; Barbara Magagna; Maisarah Nasution Waras; Alison Connolly; Marc Nascarella; Wonho Yang; Po Chin Huang; Jueun Lee; Henri Heussen; Ozlem Goksel; Masud Yunesian; Leo W.Y. Yeung; Gustavo Souza; Ana Maria Vekic; Erin N. Haynes; Nancy B. Hopf

doi:10.1016/j.envint.2025.109601

Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)

Maryam Zare Jeddi, Karen S. Galea, Jillian Ashley-Martin, Julianne Nassif, Tyler Pollock, Devika Poddalgoda, Konstantinos M. Kasiotis, Kyriaki Machera, Holger M. Koch, Marta Esteban López, Ming Kei Chung, Jihyon Kil, Kate Jones, Adrian Covaci, Yu Ait Bamai, Mariana F. Fernandez, Robert Pasanen Kase, Henriqueta Louro, Maria J. Silva, Tiina SantonenAndromachi Katsonouri, Argelia Castaño, Lesliam Quirós-Alcalá, Elizabeth Ziying Lin, Krystal Pollitt, Ana Virgolino, Paul T.J. Scheepers, Lisa Jo Melnyk, Vicente Mustieles, Ana Isabel Cañas Portilla, Susana Viegas, Natalie von Goetz, Ovnair Sepai, Emily Bird, Thomas Göen, Silvia Fustinoni, Manosij Ghosh, Hubert Dirven, Jung Hwan Kwon, Courtney Carignan, Yuki Mizuno, Yuki Ito, Yankai Xia, Shoji F. Nakayama, Konstantinos C. Makris, Patrick J. Parsons, Melissa Gonzales, Michael Bader, Maria Dusinska, Aziza Menouni, Radu Corneliu Duca, Kaoutar Chbihi, Samir El Jaafari, Lode Godderis, An van Nieuwenhuyse, Asif Qureshi, Imran Ali, Carla Costa Trindade, Joao Paulo Teixeira, Alena Bartonova, Giovanna Tranfo, Karine Audouze, Steven Verpaele, Judy LaKind, Hans Mol, Jos Bessems, Barbara Magagna, Maisarah Nasution Waras, Alison Connolly, Marc Nascarella, Wonho Yang, Po Chin Huang, Jueun Lee, Henri Heussen, Ozlem Goksel, Masud Yunesian, Leo W.Y. Yeung, Gustavo Souza, Ana Maria Vekic, Erin N. Haynes, Nancy B. Hopf

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.

Original language	English
Article number	109601
Journal	Environment international
Volume	202
DOIs	https://doi.org/10.1016/j.envint.2025.109601
State	Published - Aug 2025

Bibliographical note

Publisher Copyright:
© 2025 The Authors

Funding

We would like to thank all the experts active in the International Society for Exposure Science (ISES) European Regional Chapter, working group on Human biomonitoring (ISES Europe HBM working group) and the HBM Global Network for their support and contributions. Additionally, special thanks to ECETOC for supporting this initiative and development of www.FAIREHR.com platform. Ethical approval was not required for the work reported in this manuscript as this did not involve human subjects, human material, or human data, nor experiments on live vertebrates and/or higher invertebrates. The findings and conclusions in this presentation are those of the authors and do not necessarily represent the official position of their employers or any agency of the U.S. Government. Use of trade names is for identification only and does not imply endorsement by the EPA, CDC, or the US Department of Health and Human Services. The research presented was not performed or funded by EPA and was not subject to EPA's quality system requirements. No financial assistance was received in support of this work.

Funders	Funder number
Centers for Disease Control and Prevention
U.S. Government
International Society for Exposure Science
U.S. Department of Health and Human Services
U.S. Environmental Protection Agency

Keywords

Chemical monitoring
Contextual information
Exposome
FAIR
Harmonization
Metadata requirements

ASJC Scopus subject areas

General Environmental Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.envint.2025.109601

Cite this

Zare Jeddi, M., Galea, K. S., Ashley-Martin, J., Nassif, J., Pollock, T., Poddalgoda, D., Kasiotis, K. M., Machera, K., Koch, H. M., López, M. E., Chung, M. K., Kil, J., Jones, K., Covaci, A., Ait Bamai, Y., Fernandez, M. F., Kase, R. P., Louro, H., Silva, M. J., ... Hopf, N. B. (2025). Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM). Environment international, 202, Article 109601. https://doi.org/10.1016/j.envint.2025.109601

@article{896197fafabd47e683028352638cf8e3,

title = "Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)",

abstract = "Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.",

keywords = "Chemical monitoring, Contextual information, Exposome, FAIR, Harmonization, Metadata requirements",

author = "\{Zare Jeddi\}, Maryam and Galea, \{Karen S.\} and Jillian Ashley-Martin and Julianne Nassif and Tyler Pollock and Devika Poddalgoda and Kasiotis, \{Konstantinos M.\} and Kyriaki Machera and Koch, \{Holger M.\} and L{\'o}pez, \{Marta Esteban\} and Chung, \{Ming Kei\} and Jihyon Kil and Kate Jones and Adrian Covaci and \{Ait Bamai\}, Yu and Fernandez, \{Mariana F.\} and Kase, \{Robert Pasanen\} and Henriqueta Louro and Silva, \{Maria J.\} and Tiina Santonen and Andromachi Katsonouri and Argelia Casta{\~n}o and Lesliam Quir{\'o}s-Alcal{\'a} and Lin, \{Elizabeth Ziying\} and Krystal Pollitt and Ana Virgolino and Scheepers, \{Paul T.J.\} and Melnyk, \{Lisa Jo\} and Vicente Mustieles and \{Ca{\~n}as Portilla\}, \{Ana Isabel\} and Susana Viegas and \{von Goetz\}, Natalie and Ovnair Sepai and Emily Bird and Thomas G{\"o}en and Silvia Fustinoni and Manosij Ghosh and Hubert Dirven and Kwon, \{Jung Hwan\} and Courtney Carignan and Yuki Mizuno and Yuki Ito and Yankai Xia and Nakayama, \{Shoji F.\} and Makris, \{Konstantinos C.\} and Parsons, \{Patrick J.\} and Melissa Gonzales and Michael Bader and Maria Dusinska and Aziza Menouni and Duca, \{Radu Corneliu\} and Kaoutar Chbihi and Jaafari, \{Samir El\} and Lode Godderis and \{van Nieuwenhuyse\}, An and Asif Qureshi and Imran Ali and Trindade, \{Carla Costa\} and Teixeira, \{Joao Paulo\} and Alena Bartonova and Giovanna Tranfo and Karine Audouze and Steven Verpaele and Judy LaKind and Hans Mol and Jos Bessems and Barbara Magagna and Waras, \{Maisarah Nasution\} and Alison Connolly and Marc Nascarella and Wonho Yang and Huang, \{Po Chin\} and Jueun Lee and Henri Heussen and Ozlem Goksel and Masud Yunesian and Yeung, \{Leo W.Y.\} and Gustavo Souza and Vekic, \{Ana Maria\} and Haynes, \{Erin N.\} and Hopf, \{Nancy B.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = aug,

doi = "10.1016/j.envint.2025.109601",

language = "English",

volume = "202",

}

Zare Jeddi, M, Galea, KS, Ashley-Martin, J, Nassif, J, Pollock, T, Poddalgoda, D, Kasiotis, KM, Machera, K, Koch, HM, López, ME, Chung, MK, Kil, J, Jones, K, Covaci, A, Ait Bamai, Y, Fernandez, MF, Kase, RP, Louro, H, Silva, MJ, Santonen, T, Katsonouri, A, Castaño, A, Quirós-Alcalá, L, Lin, EZ, Pollitt, K, Virgolino, A, Scheepers, PTJ, Melnyk, LJ, Mustieles, V, Cañas Portilla, AI, Viegas, S, von Goetz, N, Sepai, O, Bird, E, Göen, T, Fustinoni, S, Ghosh, M, Dirven, H, Kwon, JH, Carignan, C, Mizuno, Y, Ito, Y, Xia, Y, Nakayama, SF, Makris, KC, Parsons, PJ, Gonzales, M, Bader, M, Dusinska, M, Menouni, A, Duca, RC, Chbihi, K, Jaafari, SE, Godderis, L, van Nieuwenhuyse, A, Qureshi, A, Ali, I, Trindade, CC, Teixeira, JP, Bartonova, A, Tranfo, G, Audouze, K, Verpaele, S, LaKind, J, Mol, H, Bessems, J, Magagna, B, Waras, MN, Connolly, A, Nascarella, M, Yang, W, Huang, PC, Lee, J, Heussen, H, Goksel, O, Yunesian, M, Yeung, LWY, Souza, G, Vekic, AM, Haynes, EN & Hopf, NB 2025, 'Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)', Environment international, vol. 202, 109601. https://doi.org/10.1016/j.envint.2025.109601

TY - JOUR

T1 - Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)

AU - Zare Jeddi, Maryam

AU - Galea, Karen S.

AU - Ashley-Martin, Jillian

AU - Nassif, Julianne

AU - Pollock, Tyler

AU - Poddalgoda, Devika

AU - Kasiotis, Konstantinos M.

AU - Machera, Kyriaki

AU - Koch, Holger M.

AU - López, Marta Esteban

AU - Chung, Ming Kei

AU - Kil, Jihyon

AU - Jones, Kate

AU - Covaci, Adrian

AU - Ait Bamai, Yu

AU - Fernandez, Mariana F.

AU - Kase, Robert Pasanen

AU - Louro, Henriqueta

AU - Silva, Maria J.

AU - Santonen, Tiina

AU - Katsonouri, Andromachi

AU - Castaño, Argelia

AU - Quirós-Alcalá, Lesliam

AU - Lin, Elizabeth Ziying

AU - Pollitt, Krystal

AU - Virgolino, Ana

AU - Scheepers, Paul T.J.

AU - Melnyk, Lisa Jo

AU - Mustieles, Vicente

AU - Cañas Portilla, Ana Isabel

AU - Viegas, Susana

AU - von Goetz, Natalie

AU - Sepai, Ovnair

AU - Bird, Emily

AU - Göen, Thomas

AU - Fustinoni, Silvia

AU - Ghosh, Manosij

AU - Dirven, Hubert

AU - Kwon, Jung Hwan

AU - Carignan, Courtney

AU - Mizuno, Yuki

AU - Ito, Yuki

AU - Xia, Yankai

AU - Nakayama, Shoji F.

AU - Makris, Konstantinos C.

AU - Parsons, Patrick J.

AU - Gonzales, Melissa

AU - Bader, Michael

AU - Dusinska, Maria

AU - Menouni, Aziza

AU - Duca, Radu Corneliu

AU - Chbihi, Kaoutar

AU - Jaafari, Samir El

AU - Godderis, Lode

AU - van Nieuwenhuyse, An

AU - Qureshi, Asif

AU - Ali, Imran

AU - Trindade, Carla Costa

AU - Teixeira, Joao Paulo

AU - Bartonova, Alena

AU - Tranfo, Giovanna

AU - Audouze, Karine

AU - Verpaele, Steven

AU - LaKind, Judy

AU - Mol, Hans

AU - Bessems, Jos

AU - Magagna, Barbara

AU - Waras, Maisarah Nasution

AU - Connolly, Alison

AU - Nascarella, Marc

AU - Yang, Wonho

AU - Huang, Po Chin

AU - Lee, Jueun

AU - Heussen, Henri

AU - Goksel, Ozlem

AU - Yunesian, Masud

AU - Yeung, Leo W.Y.

AU - Souza, Gustavo

AU - Vekic, Ana Maria

AU - Haynes, Erin N.

AU - Hopf, Nancy B.

PY - 2025/8

Y1 - 2025/8

N2 - Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.

AB - Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the “Minimum Information Requirements for Human Biomonitoring (MIR-HBM)”. This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain—such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.

KW - Chemical monitoring

KW - Contextual information

KW - Exposome

KW - FAIR

KW - Harmonization

KW - Metadata requirements

UR - https://www.scopus.com/pages/publications/105009467890

UR - https://www.scopus.com/inward/citedby.url?scp=105009467890&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2025.109601

DO - 10.1016/j.envint.2025.109601

M3 - Article

C2 - 40609511

AN - SCOPUS:105009467890

SN - 0160-4120

VL - 202

JO - Environment international

JF - Environment international

M1 - 109601

ER -

Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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