Hantaviruses and cardiopulmonary syndrome in South America

Luiz Tadeu Moraes Figueiredo, William Marciel de Souza, Marcela Ferrés, Delia Alcira Enria

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Hantavirus (Bunyaviridae) cardiopulmonary syndrome (HCPS) is an emerging health problem in South America due to urban growth and to the expansion of agriculture and cattle-raising areas into ecosystems containing most of the species of Sigmodontinae rodents that act as hantavirus reservoirs. About 4000 HCPS cases have been reported in South America up to 2013, associated with the following hantaviruses: Andes, Anajatuba, Araraquara (ARQV), Paranoá, Bermejo, Castelo dos Sonhos, Juquitiba, Araucária, Laguna Negra, Lechiguanas, Maripa, Oran, Rio Mamore and Tunari. The transmission of hantavirus to man occurs by contact with or through aerosols of excreta and secretions of infected rodents. Person-to-person transmission of hantavirus has also been reported in Argentina and Chile. HCPS courses with a capillary leaking syndrome produced by the hantavirus infecting lung endothelial cells and mostly with a severe inflammatory process associated with a cytokine storm. HCPS starts as a dengue-like acute febrile illness but after about 3 days progresses to respiratory failure and cardiogenic shock, leading to a high fatality rate that reaches 50% for patients infected with ARQV.

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalVirus Research
StatePublished - Jul 17 2014


  • Cardiopumonary syndrome
  • Emerging disease
  • Hantavirus disease
  • South-American disease

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research


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