Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia

Amina Anwar; Zena Chahine; Dava Piecoro; Melissa Kesler; Ayman Qasrawi

doi:10.1016/j.hpr.2023.300713

Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia

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Abstract

Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition.

Original language	English
Article number	300713
Journal	Human Pathology Reports
Volume	33
DOIs	https://doi.org/10.1016/j.hpr.2023.300713
State	Published - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Funding

Thanks to these individuals for their insightful clinical expertise: Dr. Rick McClure, Dr. Fevzi Yalniz, Dr. Thomas Gal, and Dr. Fadi al Nimri. Contribution: A.A. and Z.C. conceived of the presented idea. A.A. wrote the manuscript with support and editing from A.Q. and Z.C. A.Q. and Z.C. supervised the project and cared for the patients. D.W. and M.K. reviewed histological samples and provided images. All authors discussed the results and contributed to the final manuscript. Informed consent was obtained from all three patients involved in this case series. They were provided information and had had the opportunity to ask questions. The patients consented to publication of information about them in a journal or thesis.

Keywords

Diminished or absent megakaryopoiesis
Platelet disorder
Rare hematological condition

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.hpr.2023.300713

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abstract = "Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition.",

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AU - Anwar, Amina

AU - Chahine, Zena

AU - Piecoro, Dava

AU - Kesler, Melissa

AU - Qasrawi, Ayman

PY - 2023/9

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N2 - Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition.

AB - Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition.

KW - Diminished or absent megakaryopoiesis

KW - Platelet disorder

KW - Rare hematological condition

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UR - https://www.scopus.com/pages/publications/85167991003#tab=citedBy

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JO - Human Pathology Reports

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ER -

Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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