HDL cholesterol transport during inflammation

Deneys R. Van Der Westhuyzen, Frederick C. De Beer, Nancy R. Webb

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations

Abstract

PURPOSE OF REVIEW: The aim of this article is to review recent advances made towards understanding how inflammation and acute phase proteins, particularly serum amyloid A and group IIa secretory phospholipase A2, may alter reverse cholesterol transport by HDL during inflammation and the acute phase response. RECENT FINDINGS: Findings suggest that the decreased apoA-I content and markedly increased serum amyloid A content in HDL during the acute phase response result from reciprocal and coordinate transcriptional regulation of these proteins as well as HDL remodeling by group IIa secretory phospholipase A2. Serum amyloid A functions efficiently in a lipid-free or lipid-poor form to promote cholesterol efflux by ATP binding cassette protein ABCA1, evidently by functioning directly as an acceptor for cholesterol efflux as well as by increasing the availability of cellular free cholesterol. Serum amyloid A increases the ability of acute phase HDL to serve as an acceptor for SR-BI-dependent cellular cholesterol efflux. Altered remodeling of HDL by group IIa secretory phospholipase A2 in concert with cholesterol ester transfer protein may contribute to the generation of lipid-poor apoA-I and serum amyloid A acceptors for cholesterol efflux. SUMMARY: Current data support a model for the acute phase response in which serum amyloid A and sPLA2-IIa, present at sites of inflammation and tissue damage, play a protective role by enhancing cellular cholesterol efflux, thereby promoting the removal of excess cholesterol from macrophages.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalCurrent Opinion in Lipidology
Volume18
Issue number2
DOIs
StatePublished - Apr 2007

Keywords

  • Acute phase response
  • Apolipoprotein A-I
  • HDL
  • Inflammation
  • Secretory phospholipase
  • Serum amyloid A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Fingerprint

Dive into the research topics of 'HDL cholesterol transport during inflammation'. Together they form a unique fingerprint.

Cite this