Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair, Elizabeth A. Brundage, Katherine L. Thompson, Arnold Stromberg, Maya Guglin, Brandon J. Biesiadecki, Kenneth S. Campbell

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

Original languageEnglish
Pages (from-to)786-798
Number of pages13
JournalJACC: Basic to Translational Science
Volume5
Issue number8
DOIs
StatePublished - Aug 2020

Bibliographical note

Funding Information:
The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples.

Funding Information:
Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2020 The Authors

Keywords

  • Ca sensitivity
  • heart failure
  • human myocardium
  • myofilament proteins
  • ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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