This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.
|Number of pages||13|
|Journal||JACC: Basic to Translational Science|
|State||Published - Aug 2020|
Bibliographical noteFunding Information:
The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples.
Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
© 2020 The Authors
- Ca sensitivity
- heart failure
- human myocardium
- myofilament proteins
- ventricular function
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine