Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair; Elizabeth A. Brundage; Katherine L. Thompson; Arnold Stromberg; Maya Guglin; Brandon J. Biesiadecki; Kenneth S. Campbell

doi:10.1016/j.jacbts.2020.05.014

Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair, Elizabeth A. Brundage, Katherine L. Thompson, Arnold Stromberg, Maya Guglin, Brandon J. Biesiadecki, Kenneth S. Campbell

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca²⁺) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca²⁺ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

Original language	English
Pages (from-to)	786-798
Number of pages	13
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/j.jacbts.2020.05.014
State	Published - Aug 2020

Bibliographical note

Funding Information:
The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples.

Funding Information:
Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2020 The Authors

Keywords

Ca sensitivity
heart failure
human myocardium
myofilament proteins
ventricular function

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacbts.2020.05.014

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abstract = "This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.",

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note = "Funding Information: The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples. Funding Information: Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2020 The Authors",

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AU - Thompson, Katherine L.

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AU - Guglin, Maya

AU - Biesiadecki, Brandon J.

AU - Campbell, Kenneth S.

N1 - Funding Information: The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples. Funding Information: Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: © 2020 The Authors

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Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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