TY - JOUR
T1 - Helicobacter pylori neutrophil activating protein's potential as tool in therapeutic immune modulation
AU - Reyes, Victor E.
AU - Beswick, Ellen J.
PY - 2007/10
Y1 - 2007/10
N2 - Helicobacter pylori is one of the most common human pathogens and is associated with chronic gastritis, peptic ulcers and gastric carcinoma. H. pylori establishes a persistent infection, suggesting that the host response is ineffective in clearing the infection. H. pylori employs multiple mechanisms to undermine host responses. For example, CD4+ T cells are recruited to the gastric mucosa of infected individuals, but these cells are predominantly T helper 1 (TH1) cells, which do not provide protection from the extracellular pathogen. H. pylori neutrophil-activating protein (HP-NAP) promotes the TH1 polarized response. HP-NAP induces macrophages and dendritic cells to produce IL-12 and IL-23, which could explain the effect on T cells. These properties of HP-NAP make it a potential immunotherapeutic tool to redirect harmful TH2 cell responses, as seen in atopic allergy, to TH1 cell responses and also in IL-12 induction in cancer therapy.
AB - Helicobacter pylori is one of the most common human pathogens and is associated with chronic gastritis, peptic ulcers and gastric carcinoma. H. pylori establishes a persistent infection, suggesting that the host response is ineffective in clearing the infection. H. pylori employs multiple mechanisms to undermine host responses. For example, CD4+ T cells are recruited to the gastric mucosa of infected individuals, but these cells are predominantly T helper 1 (TH1) cells, which do not provide protection from the extracellular pathogen. H. pylori neutrophil-activating protein (HP-NAP) promotes the TH1 polarized response. HP-NAP induces macrophages and dendritic cells to produce IL-12 and IL-23, which could explain the effect on T cells. These properties of HP-NAP make it a potential immunotherapeutic tool to redirect harmful TH2 cell responses, as seen in atopic allergy, to TH1 cell responses and also in IL-12 induction in cancer therapy.
KW - Adjuvant
KW - Atopy
KW - Cytokines
KW - Helicobacter pylori
KW - Immune modulation
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=36148978127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36148978127&partnerID=8YFLogxK
U2 - 10.1517/13543776.17.10.1315
DO - 10.1517/13543776.17.10.1315
M3 - Article
AN - SCOPUS:36148978127
SN - 1354-3776
VL - 17
SP - 1315
EP - 1320
JO - Expert Opinion on Therapeutic Patents
JF - Expert Opinion on Therapeutic Patents
IS - 10
ER -
