TY - JOUR
T1 - Hemithyroidectomy
T2 - the preferred initial surgical approach for management of Hurthle cell neoplasm
AU - Melck, A.
AU - Bugis, S.
AU - Baliski, C.
AU - Irvine, R.
AU - Anderson, D. W.
AU - Wilkins, G.
AU - Zhang, H.
AU - Wiseman, S. M.
PY - 2006/5
Y1 - 2006/5
N2 - Background: The objective of this study was to evaluate the cancer risk of patient clinicopathologic characteristics to determine the optimal approach for the surgical management of individuals with Hurthle cell neoplasm (HN) diagnosed by cytology. Methods: Patient clinicopathologic characteristics evaluated included age, sex, tumor size, and ipsilateral thyroid lobe nodularity. The association of these characteristics with a pathologic cancer diagnosis was evaluated using Fisher's exact test and Student t test. Results: Of the 422 patients undergoing thyroidectomy, 27 presented with a fine-needle aspiration biopsy diagnosis of HN, and by pathologic assessment 7 HN patients (25.9%) had a cancer diagnosis. Although none of the clinicopathologic characteristics evaluated were able to reliably differentiate benign from malignant tumors, large tumor size and male sex were significantly associated with a pathologic diagnosis of Hurthle cell carcinoma (P < .05). Conclusions: Hemithyroidectomy represents the preferred initial surgical approach for the management of individuals presenting with nodular thyroid disease and a cytologic diagnosis of HN.
AB - Background: The objective of this study was to evaluate the cancer risk of patient clinicopathologic characteristics to determine the optimal approach for the surgical management of individuals with Hurthle cell neoplasm (HN) diagnosed by cytology. Methods: Patient clinicopathologic characteristics evaluated included age, sex, tumor size, and ipsilateral thyroid lobe nodularity. The association of these characteristics with a pathologic cancer diagnosis was evaluated using Fisher's exact test and Student t test. Results: Of the 422 patients undergoing thyroidectomy, 27 presented with a fine-needle aspiration biopsy diagnosis of HN, and by pathologic assessment 7 HN patients (25.9%) had a cancer diagnosis. Although none of the clinicopathologic characteristics evaluated were able to reliably differentiate benign from malignant tumors, large tumor size and male sex were significantly associated with a pathologic diagnosis of Hurthle cell carcinoma (P < .05). Conclusions: Hemithyroidectomy represents the preferred initial surgical approach for the management of individuals presenting with nodular thyroid disease and a cytologic diagnosis of HN.
KW - Biopsy
KW - Carcinoma
KW - Hurthle cell
KW - Needle
KW - Neoplasm
KW - Thyroid
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U2 - 10.1016/j.amjsurg.2006.02.007
DO - 10.1016/j.amjsurg.2006.02.007
M3 - Article
C2 - 16647343
AN - SCOPUS:33744480310
SN - 0002-9610
VL - 191
SP - 593
EP - 597
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 5
ER -