Hemithyroidectomy: the preferred initial surgical approach for management of Hurthle cell neoplasm

A. Melck, S. Bugis, C. Baliski, R. Irvine, D. W. Anderson, G. Wilkins, H. Zhang, S. M. Wiseman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: The objective of this study was to evaluate the cancer risk of patient clinicopathologic characteristics to determine the optimal approach for the surgical management of individuals with Hurthle cell neoplasm (HN) diagnosed by cytology. Methods: Patient clinicopathologic characteristics evaluated included age, sex, tumor size, and ipsilateral thyroid lobe nodularity. The association of these characteristics with a pathologic cancer diagnosis was evaluated using Fisher's exact test and Student t test. Results: Of the 422 patients undergoing thyroidectomy, 27 presented with a fine-needle aspiration biopsy diagnosis of HN, and by pathologic assessment 7 HN patients (25.9%) had a cancer diagnosis. Although none of the clinicopathologic characteristics evaluated were able to reliably differentiate benign from malignant tumors, large tumor size and male sex were significantly associated with a pathologic diagnosis of Hurthle cell carcinoma (P < .05). Conclusions: Hemithyroidectomy represents the preferred initial surgical approach for the management of individuals presenting with nodular thyroid disease and a cytologic diagnosis of HN.

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalAmerican Journal of Surgery
Issue number5
StatePublished - May 2006


  • Biopsy
  • Carcinoma
  • Hurthle cell
  • Needle
  • Neoplasm
  • Thyroid

ASJC Scopus subject areas

  • Surgery


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