Hemodialysis clearance of pentobarbital during continuous infusion

Daniel Werrneling, Kenneth Record, Richard Bell, William Porter, Robert Blouin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Summary: The hemodialysis clearance of pentobarbital during continuous infusion was determined in a 34-year-old man in acute renal failure. Pentobarbital specimens were obtained simultaneously from arterial blood entering and leaving the dialysis machine at five 1-h intervals. The mean hemodialysis clearance of pentobarbital was 22.3 ml/min. Pentobarbital concentration was relatively unaffected throughout the dialysis period, because of the high dose and continuous infusion of a drug with low hepatic intrinsic clearance and a short dialysis period. A large contribution to total body clearance was not evident, and dosage adjustment would have been unwarranted.

Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalTherapeutic Drug Monitoring
Volume7
Issue number4
DOIs
StatePublished - Dec 1985

Keywords

  • Continuous infusion
  • Hemodialysis
  • Pentobarbital

ASJC Scopus subject areas

  • General Medicine

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