We have extended our model of the ovine pulmonary circulation to include a model of a paracorporeal artificial lung (AL) and its attachments to the natural pulmonary circulation in two configurations: in series and in parallel. Our model of the natural lung (NL) circulation is first shown to be in agreement with hemodynamic and input impedance data from the open literature. We then study design efficacy of the AL in terms of its housing and attachments. A sensitivity analysis of the modified pulmonary circulation model reveals that there are three key parameters: inlet graft length (IGL) and the compliances of the inlet compliance chamber (CC) and housing of the artificial lung. Based on literature reports, we assume the right ventricle is well-matched to the impedance of the natural pulmonary circulation and adjust the parameters of the modeled AL circuit to achieve the best least-squares fit to pulmonary input impedance data. Best-fit parameters produce impedance curves that fit natural impedance well, particularly below 3 Hz, where both compliance and graft length have their largest effects. Of these parameters, the impedance profile is most sensitive to IGL. However, the compliances are important, as well, particularly at low frequencies.
|Number of pages||20|
|State||Published - Mar 2006|
Bibliographical noteFunding Information:
The authors would like to thank Dr. Akhil Bidani and J. Qian for useful discussions on the initial phase of this work. This project was supported by the Biomedical Engineering Center, University of Texas Medical Branch, Galveston, TX and a grant from the National Institute of Health (Grant No. R01 HL6466-0).
- Artificial lung
- Mathematical modeling
- Pulmonary circulation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine