Hemodynamic effects of the administration of tumor-infiltrating lymphocytes to cancer patients

Francesco M. Marincola, Jaikrishna Balkissoon, Douglas J. Schwartzentruber, Sophia S. Hom, Rendoll Concepcion, Stuart G. Marcus, John Yannelli, Susan L. Topalian, David R. Parkinson, Steven A. Rosenberg

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5 Scopus citations


Tumor-infiltrating lymphocytes (TILs) can mediate tumor regression in selected patients with advanced cancer. To study some of the physiological changes associated with TIL administration, hemodynamic effects were measured while 2 x 1010to 20 x 1010TILs (mean 10 ± 1 x 1010) were infused into 22 patients. In 10 patients, the first bag of TILs was administered without any interleukin-2 (IL-2) in the infusion bag; subsequent bags in the same patients and all bags in the next 12 patients contained IL-2 in low concentrations (300,000 IU). Two hours following infusion (as compared with baseline), patients developed tachycardia (110 ± 3.3 vs. 76 ± 3.5 beats/min; p<0.001), increased cardiac index (4.9 ± 0.2 vs. 3.2 ± 0.13 L/min/m2: P<0.001), decreased systemic vascular resistance (677 ± 37 vs. 1185 ± 63 dyn/s/cm5: P<0.001), and increased pulmonary artery diastolic pressure (15.9 ± 1.4 vs. 10.6 ±1.1 mm Hg; p=0.002). No significant changes in systemic blood pressure were noted. Analysis of data obtained in the 10 patients after infusion of the first bag of TILs (4.5 ± 0.4 x 1010) without IL-2 present in the infusate revealed similar, though less severe, changes. No significant correlation was noted between in vitro production of tumor necrosis factor-a, interferon--g, and granulocyte- macrophage colony-stimulating factor by TILs and hemodynamic effects when administered to patients. These results indicate that TIL infusion can cause hemodynamic changes similar to those previously reported in patients undergoing IL-2 therapy.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalJournal of Immunotherapy
Issue number4
StatePublished - May 1993


  • Hemodynamic effects
  • Interleukin-2
  • Septic shock
  • Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research


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