Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Guoqiang Yu; Turgut Durduran; Daisuke Furuya; Joel H. Greenberg; Arjun G. Yodh

doi:10.1117/12.482951

Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Guoqiang Yu, Turgut Durduran, Daisuke Furuya, Joel H. Greenberg, Arjun G. Yodh

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3λ (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1λ × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3λ × 1s × 4d for DPDW and 1λ × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4916
DOIs	https://doi.org/10.1117/12.482951
State	Published - 2002
Event	optics in Health Care and Biomedical Optics: Diagnostics and Treatment - Shanghai, China Duration: Oct 15 2002 → Oct 18 2002

Keywords

Blood oxygen saturation
Cerebral blood flow (CBF)
Cortical spreading depression (CSD)
Diffuse correlation spectroscopy (DCS)
Diffuse photon density wave (DPDW) spectroscopy
Hemodynamics
Non-contact probe

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.482951

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title = "Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies",

abstract = "Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3λ (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1λ × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3λ × 1s × 4d for DPDW and 1λ × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).",

keywords = "Blood oxygen saturation, Cerebral blood flow (CBF), Cortical spreading depression (CSD), Diffuse correlation spectroscopy (DCS), Diffuse photon density wave (DPDW) spectroscopy, Hemodynamics, Non-contact probe",

author = "Guoqiang Yu and Turgut Durduran and Daisuke Furuya and Greenberg, {Joel H.} and Yodh, {Arjun G.}",

year = "2002",

doi = "10.1117/12.482951",

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T1 - Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

AU - Yu, Guoqiang

AU - Durduran, Turgut

AU - Furuya, Daisuke

AU - Greenberg, Joel H.

AU - Yodh, Arjun G.

PY - 2002

Y1 - 2002

N2 - Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3λ (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1λ × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3λ × 1s × 4d for DPDW and 1λ × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).

AB - Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3λ (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1λ × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3λ × 1s × 4d for DPDW and 1λ × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).

KW - Blood oxygen saturation

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KW - Cortical spreading depression (CSD)

KW - Diffuse correlation spectroscopy (DCS)

KW - Diffuse photon density wave (DPDW) spectroscopy

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KW - Non-contact probe

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JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - optics in Health Care and Biomedical Optics: Diagnostics and Treatment

Y2 - 15 October 2002 through 18 October 2002

ER -

Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Abstract

Keywords

ASJC Scopus subject areas

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