Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Guoqiang Yu, Turgut Durduran, Daisuke Furuya, Joel H. Greenberg, Arjun G. Yodh

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3λ (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1λ × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3λ × 1s × 4d for DPDW and 1λ × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2002
Eventoptics in Health Care and Biomedical Optics: Diagnostics and Treatment - Shanghai, China
Duration: Oct 15 2002Oct 18 2002


  • Blood oxygen saturation
  • Cerebral blood flow (CBF)
  • Cortical spreading depression (CSD)
  • Diffuse correlation spectroscopy (DCS)
  • Diffuse photon density wave (DPDW) spectroscopy
  • Hemodynamics
  • Non-contact probe

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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