27 Scopus citations

Abstract

Over 65 % of people with obesity display the metabolic-associated fatty liver disease (MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The development and progression of MAFLD involve hepatic insulin resistance and reduced insulin clearance. This review discusses the relationships between altered insulin signaling, hepatic insulin resistance, and reduced insulin clearance in the development of MAFLD and how this provides the impetus for exploring the use of insulin sensitizers to curb this disease. The review also explores the role of the insulin receptor in hepatocytes and hepatic stellate cells and how it signals in metabolic and end-stage liver diseases. Finally, we discuss new research findings that indicate that advanced hepatic diseases may be an insulin-sensitive state in the liver and deliberate whether insulin sensitizers should be used to manage late-stage liver diseases.

Original languageEnglish
Article number155607
JournalMetabolism: Clinical and Experimental
Volume145
DOIs
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023

Keywords

  • Cirrhosis
  • Fatty liver
  • Hepatic stellate cells
  • Hepatocytes
  • Insulin clearance
  • Insulin resistance
  • Lipogenesis
  • MAFLD
  • MASH
  • NAFLD
  • NASH

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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