Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice

Ling Guo, Zhong Zheng, Junting Ai, Bin Huang, Xiang An Li

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.

Original languageEnglish
Pages (from-to)14666-14673
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number21
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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