TY - JOUR
T1 - Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice
AU - Guo, Ling
AU - Zheng, Zhong
AU - Ai, Junting
AU - Huang, Bin
AU - Li, Xiang An
PY - 2014
Y1 - 2014
N2 - Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.
AB - Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.
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U2 - 10.1074/jbc.M113.537258
DO - 10.1074/jbc.M113.537258
M3 - Article
C2 - 24719333
AN - SCOPUS:84901390752
SN - 0021-9258
VL - 289
SP - 14666
EP - 14673
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 21
ER -