Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice

Ling Guo; Zhong Zheng; Junting Ai; Bin Huang; Xiang An Li

doi:10.1074/jbc.M113.537258

Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice

Ling Guo, Zhong Zheng, Junting Ai, Bin Huang, Xiang An Li

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.

Original language	English
Pages (from-to)	14666-14673
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	21
DOIs	https://doi.org/10.1074/jbc.M113.537258
State	Published - 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.537258

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title = "Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice",

abstract = "Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.",

author = "Ling Guo and Zhong Zheng and Junting Ai and Bin Huang and Li, {Xiang An}",

year = "2014",

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TY - JOUR

T1 - Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice

AU - Guo, Ling

AU - Zheng, Zhong

AU - Ai, Junting

AU - Huang, Bin

AU - Li, Xiang An

PY - 2014

Y1 - 2014

N2 - Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.

AB - Background: We utilized Scarb1I179N mice, a model deficient in hepatic SR-BI, to determine the role of hepatic SR-BI in sepsis. Results: Upon cecal ligation and puncture (CLP), Scarb1I179N mice had a 3.5-fold increase in fatality associated with an impaired LPS clearance. Conclusion: Hepatic SR-BI protects against sepsis through promoting LPS clearance. Significance: Promoting hepatic SR-BI-mediated LPS clearance may provide a therapeutic approach for sepsis.

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ER -

Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting LPS clearance in mice

Abstract

ASJC Scopus subject areas

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