Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

DI Mohamed; SF Ezzat; WM Elayat; OA El-Kharashi; HF Abd El-Kareem; HHA Nahas; BA Abdel-Wahab; SZ Alshawwa; A Saleh; YA Helmy; E Khairy; EM Saied

doi:10.3390/ph15070832

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

DI Mohamed, SF Ezzat, WM Elayat, OA El-Kharashi, HF Abd El-Kareem, HHA Nahas, BA Abdel-Wahab, SZ Alshawwa, A Saleh, YA Helmy, E Khairy, EM Saied

Research output: Contribution to journal › Article › peer-review

Original language	American English
Article number	832
Number of pages	31
Journal	Pharmaceuticals
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/ph15070832
State	Published - Jul 2022

Keywords

DNM1L
MAPK
PGC-1 alpha
Acute heart failure
Carvedilol
Histopathology
Ischemic hepatitis
MiRNA-17
Mitofusin 2
Molecular modelling
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph15070832

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Mohamed, DI., Ezzat, SF., Elayat, WM., El-Kharashi, OA., Abd El-Kareem, HF., Nahas, HHA., Abdel-Wahab, BA., Alshawwa, SZ., Saleh, A., Helmy, YA., Khairy, E., & Saied, EM. (2022). Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study. Pharmaceuticals, 15(7), Article 832. https://doi.org/10.3390/ph15070832

@article{fec14411796f4050a75be299420d8dfb,

title = "Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study",

keywords = "DNM1L, MAPK, PGC-1 alpha, Acute heart failure, Carvedilol, Histopathology, Ischemic hepatitis, MiRNA-17, Mitofusin 2, Molecular modelling, Oxidative stress",

author = "DI Mohamed and SF Ezzat and WM Elayat and OA El-Kharashi and {Abd El-Kareem}, HF and HHA Nahas and BA Abdel-Wahab and SZ Alshawwa and A Saleh and YA Helmy and E Khairy and EM Saied",

year = "2022",

month = jul,

doi = "10.3390/ph15070832",

language = "American English",

volume = "15",

number = "7",

}

Mohamed, DI, Ezzat, SF, Elayat, WM, El-Kharashi, OA, Abd El-Kareem, HF, Nahas, HHA, Abdel-Wahab, BA, Alshawwa, SZ, Saleh, A, Helmy, YA, Khairy, E & Saied, EM 2022, 'Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study', Pharmaceuticals, vol. 15, no. 7, 832. https://doi.org/10.3390/ph15070832

TY - JOUR

T1 - Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins

T2 - An In Vivo and In Silico Study

AU - Mohamed, DI

AU - Ezzat, SF

AU - Elayat, WM

AU - El-Kharashi, OA

AU - Abd El-Kareem, HF

AU - Nahas, HHA

AU - Abdel-Wahab, BA

AU - Alshawwa, SZ

AU - Saleh, A

AU - Helmy, YA

AU - Khairy, E

AU - Saied, EM

PY - 2022/7

Y1 - 2022/7

KW - DNM1L

KW - MAPK

KW - PGC-1 alpha

KW - Acute heart failure

KW - Carvedilol

KW - Histopathology

KW - Ischemic hepatitis

KW - MiRNA-17

KW - Mitofusin 2

KW - Molecular modelling

KW - Oxidative stress

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elsevierpure&SrcAuth=WosAPI&KeyUT=WOS:000831398100001&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.3390/ph15070832

DO - 10.3390/ph15070832

M3 - Article

C2 - 35890131

SN - 1424-8247

VL - 15

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 7

M1 - 832

ER -

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

Keywords

UN SDGs

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