Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

DI Mohamed; SF Ezzat; WM Elayat; OA El-Kharashi; HF Abd El-Kareem; HHA Nahas; BA Abdel-Wahab; SZ Alshawwa; A Saleh; YA Helmy; E Khairy; EM Saied

doi:10.3390/ph15070832

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

DI Mohamed, SF Ezzat, WM Elayat, OA El-Kharashi, HF Abd El-Kareem, HHA Nahas, BA Abdel-Wahab, SZ Alshawwa, A Saleh, YA Helmy, E Khairy, EM Saied

Research output: Contribution to journal › Article › peer-review

Original language	American English
Article number	832
Number of pages	31
Journal	Pharmaceuticals
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/ph15070832
State	Published - Jul 2022

Funding

Funding: This research was funded by Faculty of Medicine, and Faculty of Science, Ain Shams University, Egypt. This research was also funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2022R141), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Keywords

DNM1L
MAPK
PGC-1 alpha
Acute heart failure
Carvedilol
Histopathology
Ischemic hepatitis
MiRNA-17
Mitofusin 2
Molecular modelling
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph15070832

Cite this

Mohamed, DI., Ezzat, SF., Elayat, WM., El-Kharashi, OA., Abd El-Kareem, HF., Nahas, HHA., Abdel-Wahab, BA., Alshawwa, SZ., Saleh, A., Helmy, YA., Khairy, E., & Saied, EM. (2022). Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study. Pharmaceuticals, 15(7), Article 832. https://doi.org/10.3390/ph15070832

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keywords = "DNM1L, MAPK, PGC-1 alpha, Acute heart failure, Carvedilol, Histopathology, Ischemic hepatitis, MiRNA-17, Mitofusin 2, Molecular modelling, Oxidative stress",

author = "DI Mohamed and SF Ezzat and WM Elayat and OA El-Kharashi and \{Abd El-Kareem\}, HF and HHA Nahas and BA Abdel-Wahab and SZ Alshawwa and A Saleh and YA Helmy and E Khairy and EM Saied",

year = "2022",

month = jul,

doi = "10.3390/ph15070832",

language = "American English",

volume = "15",

number = "7",

}

Mohamed, DI, Ezzat, SF, Elayat, WM, El-Kharashi, OA, Abd El-Kareem, HF, Nahas, HHA, Abdel-Wahab, BA, Alshawwa, SZ, Saleh, A, Helmy, YA, Khairy, E & Saied, EM 2022, 'Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study', Pharmaceuticals, vol. 15, no. 7, 832. https://doi.org/10.3390/ph15070832

TY - JOUR

T1 - Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins

T2 - An In Vivo and In Silico Study

AU - Mohamed, DI

AU - Ezzat, SF

AU - Elayat, WM

AU - El-Kharashi, OA

AU - Abd El-Kareem, HF

AU - Nahas, HHA

AU - Abdel-Wahab, BA

AU - Alshawwa, SZ

AU - Saleh, A

AU - Helmy, YA

AU - Khairy, E

AU - Saied, EM

PY - 2022/7

Y1 - 2022/7

KW - DNM1L

KW - MAPK

KW - PGC-1 alpha

KW - Acute heart failure

KW - Carvedilol

KW - Histopathology

KW - Ischemic hepatitis

KW - MiRNA-17

KW - Mitofusin 2

KW - Molecular modelling

KW - Oxidative stress

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elsevierpure&SrcAuth=WosAPI&KeyUT=WOS:000831398100001&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.3390/ph15070832

DO - 10.3390/ph15070832

M3 - Article

C2 - 35890131

SN - 1424-8247

VL - 15

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 7

M1 - 832

ER -

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

Funding

Keywords

UN SDGs

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