Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, and Regulation

Vijay K. Nandula, Dean E. Riechers, Yurdagul Ferhatoglu, Michael Barrett, Stephen O. Duke, Franck E. Dayan, Alina Goldberg-Cavalleri, Catherine Tétard-Jones, David J. Wortley, Nawaporn Onkokesung, Melissa Brazier-Hicks, Robert Edwards, Todd Gaines, Satoshi Iwakami, Mithila Jugulam, Rong Ma

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Several grass and broadleaf weed species around the world have evolved multiple-herbicide resistance at alarmingly increasing rates. Research on the biochemical and molecular resistance mechanisms of multiple-resistant weed populations indicate a prevalence of herbicide metabolism catalyzed by enzyme systems such as cytochrome P450 monooxygenases and glutathione S-transferases and, to a lesser extent, by glucosyl transferases. A symposium was conducted to gain an understanding of the current state of research on metabolic resistance mechanisms in weed species that pose major management problems around the world. These topics, as well as future directions of investigations that were identified in the symposium, are summarized herein. In addition, the latest information on selected topics such as the role of safeners in inducing crop tolerance to herbicides, selectivity to clomazone, glyphosate metabolism in crops and weeds, and bioactivation of natural molecules is reviewed.

Original languageEnglish
Pages (from-to)149-175
Number of pages27
JournalWeed Science
Issue number2
StatePublished - Mar 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Weed Science Society of America.


  • Crop tolerance
  • cytochrome P450
  • glutathione
  • glutathione S -transferase
  • herbicide safener
  • natural phytotoxin
  • oxylipin

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science


Dive into the research topics of 'Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, and Regulation'. Together they form a unique fingerprint.

Cite this