TY - JOUR
T1 - Herpes Simplex Virus-Specific Lymphoproliferation
T2 - An Analysis of the Involvement of Lymphocyte Subsets
AU - Horohov, D. W.
AU - Moore, R. N.
AU - Rouse, B. T.
PY - 1985
Y1 - 1985
N2 - Herpes simplex virus (HSV)-immune murine splenocytes incorporated significant levels of tritiated thymidine when incubated with UV-inactivated, heat-inactivated, and active preparations of HSVNormal splenocytes incubated with the HSV preparations did not exhibit such proliferationMaximum incorporation by the immune splenocytes occurred on the fifth day of culture and was mediated by Thy-1+, Lyt-1+, and Lyt-2+ cellsAttempts to correlate lymphoproliferation with other HSV-specific cellular immune responses demonstrated the complexity of this responseWhile T cells mediating delayed type hypersensitivity responses and cytotoxic T lymphocytes were involved in the lymphoproliferative response, neither could be considered as being exclusively associated with lymphoproliferationInstead, lymphoproliferation appeared to be indicative of HSV-specific Lyt-1+ helper cellsEvidence was also presented that suppressor cells appeared to be involved in the regulation of the lymphoproliferative response.
AB - Herpes simplex virus (HSV)-immune murine splenocytes incorporated significant levels of tritiated thymidine when incubated with UV-inactivated, heat-inactivated, and active preparations of HSVNormal splenocytes incubated with the HSV preparations did not exhibit such proliferationMaximum incorporation by the immune splenocytes occurred on the fifth day of culture and was mediated by Thy-1+, Lyt-1+, and Lyt-2+ cellsAttempts to correlate lymphoproliferation with other HSV-specific cellular immune responses demonstrated the complexity of this responseWhile T cells mediating delayed type hypersensitivity responses and cytotoxic T lymphocytes were involved in the lymphoproliferative response, neither could be considered as being exclusively associated with lymphoproliferationInstead, lymphoproliferation appeared to be indicative of HSV-specific Lyt-1+ helper cellsEvidence was also presented that suppressor cells appeared to be involved in the regulation of the lymphoproliferative response.
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U2 - 10.1016/S0171-2985(85)80069-3
DO - 10.1016/S0171-2985(85)80069-3
M3 - Article
C2 - 3005161
AN - SCOPUS:0022378133
SN - 0171-2985
VL - 170
SP - 460
EP - 473
JO - Immunobiology
JF - Immunobiology
IS - 5
ER -