Abstract
Xiang and colleagues report a method for generating human thalamus-like brain organoids (hThOs) that recapitulate the development of human thalamus. By fusing hThOs and cortical-like brain organoids (hCOs), they establish a 3D system in a dish to create the reciprocal projections between thalamus and cortex.
Original language | English |
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Pages (from-to) | 487-497.e7 |
Journal | Cell Stem Cell |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Mar 7 2019 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc.
Keywords
- brain organoid
- cortex
- corticothalamic
- fusion
- hESC
- single cell RNA-seq
- thalamic organoid
- thalamocortical
- thalamus
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology