hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

Yangfei Xiang, Yoshiaki Tanaka, Bilal Cakir, Benjamin Patterson, Kun Yong Kim, Pingnan Sun, Young Jin Kang, Mei Zhong, Xinran Liu, Prabir Patra, Sang Hun Lee, Sherman M. Weissman, In Hyun Park

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

Xiang and colleagues report a method for generating human thalamus-like brain organoids (hThOs) that recapitulate the development of human thalamus. By fusing hThOs and cortical-like brain organoids (hCOs), they establish a 3D system in a dish to create the reciprocal projections between thalamus and cortex.

Original languageEnglish
Pages (from-to)487-497.e7
JournalCell Stem Cell
Volume24
Issue number3
DOIs
StatePublished - Mar 7 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • brain organoid
  • cortex
  • corticothalamic
  • fusion
  • hESC
  • single cell RNA-seq
  • thalamic organoid
  • thalamocortical
  • thalamus

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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