Heterozygotes for ACAN dwarfism alleles in horses have reduced stature

K. T. Graves, J. E. Eberth, E. Bailey

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Homozygous and compound heterozygous Miniature horses for ACAN alleles D1, D2, D3* and D4 exhibit chondrodysplastic dwarfism (OMIA 001271-9796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism-causing alleles had a shorter withers height than non-carriers. A total of 245 Miniature horses were tested for these four ACAN alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non-carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (P = 1.72E − 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism-causing variants may be due to selection for decreased height.

Original languageEnglish
Pages (from-to)420-422
Number of pages3
JournalAnimal Genetics
Issue number3
StatePublished - Jun 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Stichting International Foundation for Animal Genetics


  • Miniature horse
  • aggrecan
  • pony
  • selection
  • size

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics


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