Homozygous and compound heterozygous Miniature horses for ACAN alleles D1, D2, D3* and D4 exhibit chondrodysplastic dwarfism (OMIA 001271-9796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism-causing alleles had a shorter withers height than non-carriers. A total of 245 Miniature horses were tested for these four ACAN alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non-carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (P = 1.72E − 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism-causing variants may be due to selection for decreased height.
|Number of pages||3|
|State||Published - Jun 1 2020|
Bibliographical noteFunding Information:
This manuscript is published in connection with a project of the University of Kentucky Agricultural Experiment Station.
© 2020 Stichting International Foundation for Animal Genetics
- Miniature horse
ASJC Scopus subject areas
- Animal Science and Zoology