TY - JOUR
T1 - High density lipoprotein protects against polymicrobe-induced sepsis in mice
AU - Guo, Ling
AU - Ai, Junting
AU - Zheng, Zhong
AU - Howatt, Deborah A.
AU - Daugherty, Alan
AU - Huang, Bin
AU - Li, Xiang An
PY - 2013/6/21
Y1 - 2013/6/21
N2 - Background: The role of HDL in sepsis remains to be clarified. Results: ApoA-I-KO mice are susceptible but apoA-I-tg mice are resistant to CLP-induced sepsis. Lack of HDL leads to less LPS neutralization, less LPS clearance, impaired leukocyte recruitment, and reduced corticosterone generation in sepsis. Conclusion: HDL exerts multiple protective effects in polymicrobe-induced sepsis. Significance: Our study supports efforts to raise HDL levels as a therapeutic approach for sepsis.
AB - Background: The role of HDL in sepsis remains to be clarified. Results: ApoA-I-KO mice are susceptible but apoA-I-tg mice are resistant to CLP-induced sepsis. Lack of HDL leads to less LPS neutralization, less LPS clearance, impaired leukocyte recruitment, and reduced corticosterone generation in sepsis. Conclusion: HDL exerts multiple protective effects in polymicrobe-induced sepsis. Significance: Our study supports efforts to raise HDL levels as a therapeutic approach for sepsis.
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U2 - 10.1074/jbc.M112.442699
DO - 10.1074/jbc.M112.442699
M3 - Article
C2 - 23658016
AN - SCOPUS:84880069808
SN - 0021-9258
VL - 288
SP - 17947
EP - 17953
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 25
ER -