High-Density Lipoproteins and Serum Amyloid A (SAA)

Nancy R. Webb

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Purpose of Review: Serum amyloid A (SAA) is a highly sensitive acute phase reactant that has been linked to a number of chronic inflammatory diseases. During a systemic inflammatory response, liver-derived SAA is primarily found on high-density lipoprotein (HDL). The purpose of this review is to discuss recent literature addressing the pathophysiological functions of SAA and the significance of its association with HDL. Recent Findings: Studies in gene-targeted mice establish that SAA contributes to atherosclerosis and some metastatic cancers. Accumulating evidence indicates that the lipidation state of SAA profoundly affects its bioactivities, with lipid-poor, but not HDL-associated, SAA capable of inducing inflammatory responses in vitro and in vivo. Factors that modulate the equilibrium between lipid-free and HDL-associated SAA have been identified. Summary: HDL may serve to limit SAA’s bioactivities in vivo. Understanding the factors leading to the release of systemic SAA from HDL may provide insights into chronic disease mechanisms.

Original languageEnglish
Article number7
JournalCurrent Atherosclerosis Reports
Issue number2
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).


  • Acute phase response
  • Atherosclerosis
  • HDL remodeling
  • Inflammation
  • Innate immunity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'High-Density Lipoproteins and Serum Amyloid A (SAA)'. Together they form a unique fingerprint.

Cite this